Effect of nut consumption on vascular endothelial function: A systematic review and meta-analysis of randomized controlled trials
Xiao Y, Huang W, Peng C, Zhang J, Wong C, Kim JH, Yeoh EK, Su X
Clinical nutrition (Edinburgh, Scotland) · 42 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Guangdong Provincial Medical Research Fund
- Subvenciones
- National Natural Science Foundation of China (81402672)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2017-04-20 · Clin Nutr · vol. 37 · número 3 · págs. 831–839
- Editorial
- Elsevier BV
- Citado
- 65 citas · más que el 76% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 53 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nuts composition and effects · Cardiovascular Health and Disease Prevention · Nutritional Studies and Diet
- Palabras clave
- nut consumption, endothelial function, flow-mediated dilation, Juglans regia, cardiovascular disease, dietary intervention
- MeSH
- endothelium, vascular, humans, juglans, nuts, cardiovascular diseases, diet, cross-over studies, vasodilation, adult, aged, middle aged, hemodynamics, randomized controlled trials as topic
8 autores
- Yunjun Xiao🇨🇳 · autor de correspondenciaShenzhen Center for Disease Control and Prevention
- Wei Huang🇨🇳Shenzhen Center for Disease Control and Prevention
- Chaoqiong Peng🇨🇳Shenzhen Center for Disease Control and Prevention
- Jinzhou Zhang🇨🇳Shenzhen Center for Disease Control and Prevention
- Carmen Ka Man Wong🇭🇰Chinese University of Hong Kong
- Jean H. Kim🇭🇰Chinese University of Hong Kong
- Eng‐Kiong Yeoh🇭🇰Chinese University of Hong Kong
- Xuefen Su🇭🇰🇨🇳 · autor de correspondenciaChinese University of Hong Kong; Chinese University of Hong Kong, Shenzhen
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
nut consumption has consistently been found to be associated with a reduced risk of cardiovascular diseases (CVD) and mortality in prospective studies. However, its effect on endothelial function, a prognostic marker of CVD, is still controversial in clinical trials. This meta-analysis of randomized controlled trials (RCTs) aimed to quantitatively assess the effect of nuts on vascular endothelial function.
Methods
Major electronic databases were searched for published RCTs that reported the effect of nuts on flow mediated dilation (FMD) as a measurement of endothelial function in the adult population (age eighteen years or over). We calculated the pooled estimates of weighted mean differences (WMDs) and their 95% confidence intervals (CIs) by using random-effects models.
Results
A total of nine papers (10 trials) involving 374 participants were included. The pooled estimates found that nut consumption significantly improved FMD (WMD: 0.41%; 95% CI: 0.18%, 0.63%; P = 0.001). Moderate and marginally significant heterogeneity was observed among the studies (I2 = 39.5%, P = 0.094). Subgroup analyses indicated that walnuts significantly improved FMD (WMD: 0.39%; 95% CI: 0.16%, 0.63%; P = 0.001). In addition, nut consumption had a significant effect on FMD in the trials with study duration <18 weeks, nut dose <67 g/d, or subjects with baseline FMD ≥8.6%.
Conclusions
Nut consumption significantly improved endothelial function. However, the beneficial effect was limited to walnuts. More studies examining the effect of other nuts on endothelial function are needed in the future.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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