Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions
Choudhary D, Bhattacharyya S, Bose S
Journal of dietary supplements · 126 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2017-02-21 · J Diet Suppl · vol. 14 · número 6 · págs. 599–612
- Editorial
- Taylor & Francis
- Citado
- 214 citas · más que el 99% de estudios similares · 16.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- De pago
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Medicinal Plants and Neuroprotection · Pharmacology and Nanomedicine Research
- Palabras clave
- Withania somnifera, Placebo, Cognition, Wechsler Adult Intelligence Scale, Wechsler Memory Scale, Executive functions, Medicine, Memory test, Echoic memory, Verbal memory, Audiology, Trail Making Test, Psychology, Cognitive impairment, Psychiatry
- MeSH
- humans, withania, plant roots, plant extracts, phytotherapy, prospective studies, pilot projects, double-blind method, sample size, cognition, memory, adult, middle aged, cognitive dysfunction
3 autores
- Dnyanraj Choudhary
- Sauvik Bhattacharyya · autor de correspondencia
- Sekhar Kumar Bose
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Cognitive decline is often associated with the aging process. Ashwagandha (Withania somnifera (L.) Dunal) has long been used in the traditional Ayurvedic system of medicine to enhance memory and improve cognition.
Aim
This pilot study was designed to evaluate the efficacy and safety of ashwagandha (Withania somnifera (L.) Dunal) in improving memory and cognitive functioning in adults with mild cognitive impairment (MCI).
Methods
A prospective, randomized, double-blind, placebo-controlled study was conducted in 50 adults. Subjects were treated with either ashwagandha-root extract (300 mg twice daily) or placebo for eight weeks.
Results
After eight weeks of study, the ashwagandha treatment group demonstrated significant improvements compared with the placebo group in both immediate and general memory, as evidenced by Wechsler Memory Scale III subtest scores for logical memory I (p = 0.007), verbal paired associates I (p = 0.042), faces I (p = 0.020), family pictures I (p = 0.006), logical memory II (p = 0.006), verbal paired associates II (p = 0.031), faces II (p = 0.014), and family pictures II (p = 0.006). The treatment group also demonstrated significantly greater improvement in executive function, sustained attention, and information-processing speed as indicated by scores on the Eriksen Flanker task (p = 0.002), Wisconsin Card Sort test (p = 0.014), Trail-Making test part A (p = 0.006), and the Mackworth Clock test (p = 0.009).
Conclusions
Ashwagandha may be effective in enhancing both immediate and general memory in people with MCI as well as improving executive function, attention, and information processing speed.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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