Dose-response relationship between dietary magnesium intake, serum magnesium concentration and risk of hypertension: a systematic review and meta-analysis of prospective cohort studies
Han H, Fang X, Wei X, Liu Y, Jin Z, Chen Q, Fan Z, Aaseth J, Hiyoshi A, He J, Cao Y
Nutrition journal · 107 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Örebro Universitet
- Universidad u hospital
- Karolinska Institutet
- Universidad u hospital
- Second Military Medical University
- Gobierno
- Chinese Fourth Round of the Three-year Action Plan on Public Health Discipline and Talent Program
- Subvenciones
- Karolinska Institutet (C62412022)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-05-05 · Nutr J · vol. 16 · número 1 · pág. 26
- Editorial
- BioMed Central
- Citado
- 166 citas · más que el 90% de estudios similares · 1.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 64 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Sodium Intake and Health
- Palabras clave
- Medicine, Prospective cohort study, Magnesium, Relative risk, Cohort study, Internal medicine, Meta-analysis, Cochrane Library, Cohort, Magnesium deficiency (plants), Risk factor, Confidence interval, Endocrinology
- MeSH
- hypertension, magnesium, risk factors, blood pressure, dose-response relationship, drug, databases, factual, recommended dietary allowances
11 autores
- Hedong Han🇨🇳Second Military Medical University
- Xin Lei Fang🇸🇪 · autor de correspondenciaKarolinska Institutet
- Xin Wei
- Yuzhou Liu
- Zhicao Jin🇨🇳Second Military Medical University
- Qi Chen🇨🇳Second Military Medical University
- Zhongjie Fan🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Jan Aaseth🇳🇴Innlandet Hospital Trust
- Ayako Hiyoshi🇸🇪Örebro University
- Jia He🇨🇳 · autor de correspondenciaSecond Military Medical University
- Yang Cao🇸🇪Örebro University; Karolinska Institutet
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The findings of prospective cohort studies are inconsistent regarding the association between dietary magnesium intake and serum magnesium concentration and the risk of hypertension. We aimed to review the evidence from prospective cohort studies and perform a dose-response meta-analysis to investigate the relationship between dietary magnesium intake and serum magnesium concentrations and the risk of hypertension.
Methods
We searched systematically PubMed, EMBASE and the Cochrane Library databases from October 1951 through June 2016. Prospective cohort studies reporting effect estimates with 95% confidence intervals (CIs) for hypertension in more than two categories of dietary magnesium intake and/or serum magnesium concentrations were included. Random-effects models were used to combine the estimated effects.
Results
Nine articles (six on dietary magnesium intake, two on serum magnesium concentration and one on both) of ten cohort studies, including 20,119 cases of hypertension and 180,566 participates, were eligible for inclusion in the meta-analysis. We found an inverse association between dietary magnesium intake and the risk of hypertension [relative risk (RR) = 0.92; 95% CI: 0.86, 0.98] comparing the highest intake group with the lowest. A 100 mg/day increment in magnesium intake was associated with a 5% reduction in the risk of hypertension (RR = 0.95; 95% CI: 0.90, 1.00). The association of serum magnesium concentration with the risk of hypertension was marginally significant (RR = 0.91; 95% CI: 0.80, 1.02).
Conclusions
Current evidence supports the inverse dose-response relationship between dietary magnesium intake and the risk of hypertension. However, the evidence about the relationship between serum magnesium concentration and hypertension is limited.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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