Effect of Magnesium Supplementation on Plasma C-reactive Protein Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Simental-Mendia LE, Sahebkar A, Rodriguez-Moran M, Zambrano-Galvan G, Guerrero-Romero F
Current pharmaceutical design · 60 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2017-05-26 · Curr Pharm Des · vol. 23 · número 31 · págs. 4678–4686
- Editorial
- Bentham Science Publishers
- Citado
- 83 citas · más que el 79% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Adipokines, Inflammation, and Metabolic Diseases · Therapeutic Uses of Natural Elements
- Palabras clave
- Meta-analysis, Randomized controlled trial, Medicine, C-reactive protein, Magnesium, Internal medicine, Gastroenterology, Subgroup analysis, Publication bias, Random effects model, Strictly standardized mean difference, Inflammation, Chemistry
- MeSH
- humans, inflammation, magnesium, c-reactive protein, dietary supplements, randomized controlled trials as topic
5 autores
- Luis E. Simental‐Mendía🇲🇽Mexican Social Security Institute
- Amirhossein Sahebkar🇮🇷Mashhad University of Medical Sciences; Biotechnology Research Center
- Martha Rodríguez‐Morán🇲🇽Mexican Social Security Institute
- Graciela Zambrano-Galván🇲🇽Universidad Juárez del Estado de Durango
- Fernando Guerrero‐Romero🇲🇽 · autor de correspondenciaMexican Social Security Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Results of previous clinical trials evaluating the effect of magnesium supplementation on inflammatory markers are controversial.
Objective
A systematic review and meta-analysis of randomized controlled trials (RCTs) were performed to evaluating the effect of oral magnesium supplementation on plasma C-reactive protein (CRP) concentrations.
Method
PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases were searched (from inception to August 09, 2016) to identify RCTs, evaluating the effect of magnesium on CRP levels. A random-effects model and a generic inverse variance method were used to compensate for the heterogeneity of studies. Publication bias, sensitivity analysis, and meta-regression assessments were conducted using standard methods.
Results
Overall, the impact of magnesium supplementation on plasma concentrations of CRP was assessed in 11 studies. Magnesium treatment was not found to significantly affect plasma concentrations of CRP (WMD: -0.11 mg/L, 95% CI: -0.75, 0.52, p=0.727). When the analysis was stratified to compare subgroups of studies in populations with baseline plasma CRP values of ≤ 3 and > 3 mg/L, a significant reduction of CRP values was observed in the latter subgroup (WMD: -1.12 mg/L, 95% CI: -2.05, -0.18, p=0.019) but not in the former group (WMD: 0.61 mg/L, 95% CI: -0.10, 1.32, p=0.090). The difference between subgroups was statistically significant (p=0.004).
Conclusion
Results of the present meta-analysis indicated that magnesium supplementation reduces CRP levels among individuals with inflammation (CRP levels > 3 mg/dL). This finding suggests that magnesium supplements may have a beneficial role as an adjuvant for the management of low-grade chronic systemic inflammation.
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