Effect of laser photobiomodulation on wound healing and postoperative pain following free gingival graft: A split-mouth triple-blind randomized controlled clinical trial
Heidari M, Paknejad M, Jamali R, Nokhbatolfoghahaei H, Fekrazad R, Moslemi N
Journal of photochemistry and photobiology. B, Biology · 49 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Laser Research Center of Dentistry, Dental Research Institute, Tehran University of Medical Sciences, Tehran, Iran
Según 1 financiador declarado.
Publicación
- Publicado
- 2017-05-18 · J Photochem Photobiol B · vol. 172 · págs. 109–114
- Editorial
- Elsevier BV
- Citado
- 71 citas · más que el 95% de estudios similares · 4.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Periodontal Regeneration and Treatments · Wound Healing and Treatments
- Palabras clave
- laser photobiomodulation, free gingival graft, gingival augmentation, wound healing, postoperative pain, re-epithelialization, donor site, low-level laser therapy
- MeSH
- gingiva, humans, mouth diseases, anti-inflammatory agents, non-steroidal, placebo effect, wound healing, adult, middle aged, female, male, lasers, semiconductor, low-level light therapy, postoperative pain
6 autores
- Mohadeseh Heidari🇮🇷Tehran University of Medical Sciences
- Mojgan Paknejad🇮🇷Tehran University of Medical Sciences
- Raika Jamali🇮🇷Sina Hospital; Tehran University of Medical Sciences
- Hanieh Nokhbatolfoghahaei🇮🇷Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Reza Fekrazad🇮🇷Aja University of Medical Sciences; Universal Scientific Education and Research Network
- Neda Moslemi🇮🇷 · autor de correspondenciaTehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aim
Free gingival graft (FGG) is one of the most predictable techniques for gingival augmentation. However, patient's discomfort and pain during healing period are significant concerns. The aim of this study was to assess if laser photobiomodulation (PBM) was effective in terms of enhancing wound healing and reducing postoperative pain.
Methods and materials
Twelve patients participated in this split-mouth randomized controlled clinical trial. Each patient had a 30-day interval between the two procedures. In the test group, donor and recipient sites received diode laser (660nm, 200mW, continuous mode, time of irradiation:32s, energy density: 4J/cm2, spot size:0.5cm) immediately after FGG surgery, and 1,2,4 and 7days later. The control side received the same sequence of irradiation with the laser-off. Complete wound epithelialization of donor site and clinical wound healing and visual analogue scale (VAS) pain score of donor and recipient sites were evaluated after surgery.
Results
At 14 and 21days after surgery, the number of donor sites with complete epithelialization was greater in laser group compared to the placebo. After 21days, all donor sites in the test group were epithelialized completely, while at the same time, only eight donor sites in the control group showed complete epithelialization (P value=0.05). In terms of clinical healing of the recipient and donor sites, the test and control groups did not show any significant difference during the 45-day period, except at days 1 (for recipient site) and 14 (for donor site), when the test group showed better results (P values: 0.01 and 0.03, respectively). The VAS pain score did not show statistically significant difference between two groups during the study period, except for the first 3h after procedure when laser group showed greater VAS pain score (P values<0.05).
Conclusion
PBM following FGG procedure with the parameters used in this study could accelerate the rate of epithelialization at the donor site. However, it did not reduce postoperative pain.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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