No impact of fish oil supplements on bleeding risk: a systematic review
Begtrup KM, Krag AE, Hvas AM
Danish medical journal · 16 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2017-05-01 · Dan Med J · vol. 64 · número 5
- Editorial
- National Institutes of Health
- Citado
- 35 citas · más que el 92% de estudios similares · 2.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Trauma, Hemostasis, Coagulopathy, Resuscitation · Hemostasis and retained surgical items · Fatty Acid Research and Health
- Palabras clave
- Medicine, Fish oil, Fish <Actinopterygii>, MEDLINE, Environmental health, Fishery
- MeSH
- humans, blood loss, surgical, postoperative hemorrhage, fish oils, risk assessment, dietary supplements, randomized controlled trials as topic
3 autores
- Katrine Munk Begtrup
- Andreas Engel Krag
- Anne‐Mette Hvas
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Fish oil supplementation may inhibit platelet aggregation and can potentially increase the risk of bleeding. The aim of the present systematic review was to evaluate the effect of fish oil supplements on haemostasis and bleeding risk, and to provide recommendations on whether it is necessary to discontinue fish oil supplementation prior to surgery.
Methods
Studies were identified through PubMed and Embase searches and by reviewing the reference lists of the included papers. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used. Included in the review were publications including a minimum of 20 healthy subjects and studies on patients who were undergoing surgery and who had fish oil exposure.
Results
In total, 52 publications were included; 32 publications on healthy subjects and 20 publications on patients undergoing surgery. The majority of the included studies were randomised controlled trials or included a control group. Overall, fish oil supplements reduced platelet aggregation in healthy subjects. Fish oil exposure in surgical patients did not increase bleeding or blood transfusions either during or after surgery.
Conclusion
Fish oil supplements reduced platelet aggregation in healthy subjects. This biochemical effect was not reflected in increased bleeding risk during or after surgery evaluated in randomised controlled trials. Consequently, this systematic review does not support the need for discontinuation of fish oil supplements prior to surgery or other invasive procedures.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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