Dietary nitrate does not modify blood pressure and cardiac output at rest and during exercise in older adults: a randomised cross-over study
Oggioni C, Jakovljevic DG, Klonizakis M, Ashor AW, Ruddock A, Ranchordas M, Williams E, Siervo M
International journal of food sciences and nutrition · 24 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Newcastle University
- Gobierno
- Medical Research Council
- Gobierno
- MRC – Arthritis Research
- Universidad u hospital
- Sheffield University of Sheffield
- Subvenciones
- Medical Research Council (MR/N007921/1); Medical Research Council (MR/K006312/1); Medical Research Council (MR/L016354/1)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-05-31 · Int J Food Sci Nutr · vol. 69 · número 1 · págs. 74–83
- Editorial
- Taylor & Francis
- Citado
- 30 citas · más que el 85% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 36 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Cardiovascular Health and Disease Prevention · Cardiovascular and exercise physiology · Nitric Oxide and Endothelin Effects
- Palabras clave
- Medicine, Placebo, Blood pressure, Oxidative stress, Internal medicine, Cardiac function curve, Cardiology, Diastole, Inflammation, Physiology, Physical therapy, Randomized controlled trial, Pathology, Heart failure
- MeSH
- humans, beta vulgaris, plant roots, nitrates, cardiac output, exercise test, anthropometry, exercise, diet, cross-over studies, double-blind method, life style, blood pressure, aged, middle aged, female, male, gas chromatography-mass spectrometry, biomarkers, surveys and questionnaires, fruit and vegetable juices
8 autores
- Clio Oggioni🇬🇧Newcastle University
- Djordje G. Jakovljević🇬🇧Newcastle University
- Markos Klonizakis🇬🇧Sheffield Hallam University
- Ammar Waham Ashor🇬🇧Newcastle University
- Alan D. Ruddock🇬🇧Sheffield Hallam University
- Mayur Krachna Ranchordas🇬🇧Sheffield Hallam University
- Elizabeth A. Williams🇬🇧University of Sheffield
- Mario Siervo🇬🇧 · autor de correspondenciaNewcastle University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary nitrate (NO3-) supplementation has been associated with improved vascular and metabolic health. We conducted a double-blind, cross-over, placebo-controlled RCT to investigate the effects of 7-d consumption of beetroot juice compared with placebo on (1) blood pressure (BP) measured in resting conditions and during exercise, (2) cardiac and peripheral vascular function and (3) biomarkers of inflammation, oxidative stress and endothelial integrity. Twenty non-smoking healthy participants aged 60-75 years and BMI 20.0-29.9 kg/m2 were recruited. Measurement was conducted before and after each 7-d intervention period. Consumption of NO3- had no effect on resting systolic and diastolic BP. NO3- consumption did not improve indexes of central and peripheral cardiac function responses during cardiopulmonary exercise testing. Dietary NO3- supplementation did not modify biomarkers of inflammation, oxidative stress and endothelial integrity. This study does not support the short-term benefits of dietary NO3- supplementation on physiological and biochemical markers of vascular health in older healthy adults.
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