Effects of Cholecalciferol Supplementation in Patients with stable heart failure and LOw vITamin D levels (ECSPLOIT-D): a double-blind, randomized, placebo-controlled pilot study
Turrini F, Scarlini S, Giovanardi P, Messora R, Roli L, Chester J, Mussi C, Bertolotti M, Trenti T, Bondi M
Minerva cardioangiologica · 13 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2017-09-01 · Minerva Cardioangiol · vol. 65 · número 6 · págs. 553–562
- Editorial
- Edizioni Minerva Medica
- Citado
- 17 citas · más que el 75% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Cardiovascular Function and Risk Factors · Heart Failure Treatment and Management
- Palabras clave
- Placebo, Medicine, Cholecalciferol, Vitamin D and neurology, Clinical endpoint, Heart failure, Internal medicine, vitamin D deficiency, Hormone, Placebo group, Randomized controlled trial, Vitamin, Gastroenterology, Endocrinology
- MeSH
- humans, vitamin d deficiency, cholecalciferol, echocardiography, exercise test, treatment outcome, follow-up studies, pilot projects, double-blind method, time factors, dietary supplements, aged, aged, 80 and over, female, male, heart failure
10 autores
- Fabrizio Turrini🇮🇹Azienda Unita' Sanitaria Locale Di Modena
- Stefania Scarlini🇮🇹Azienda Unita' Sanitaria Locale Di Modena
- Paolo Giovanardi🇮🇹Azienda Unita' Sanitaria Locale Di Modena
- R Messora🇮🇹Azienda Unita' Sanitaria Locale Di Modena
- Laura Roli🇮🇹Azienda Unita' Sanitaria Locale Di Modena
- Johanna Chester🇮🇹Azienda Unita' Sanitaria Locale Di Modena
- Chiara Erminia Mussi🇮🇹Azienda Unita' Sanitaria Locale Di Modena
- Marco Bertolotti🇮🇹Azienda Unita' Sanitaria Locale Di Modena
- Tommaso Trenti🇮🇹Azienda Unita' Sanitaria Locale Di Modena
- Marco Bondi🇮🇹Azienda Unita' Sanitaria Locale Di Modena
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The aim of this study was to investigate the effects of vitamin D (VD) on the interaction among functional, echocardiographic and hormonal parameters in patients with heart failure (HF) and VD deficiency.
Methods
In a randomized, double blind trial, 35 patients with HF and VD<20 ng/mL, received either 300,000 U of oral cholecalciferol followed by 50,000 U/month for 6 months, or placebo treatment.
Results
Changes in the 6 Minute Walking Test (6MWT) assessed at 3 and 6 months in treatment group was the primary end point. Secondary endpoints were echocardiographic and hormonal changes. The same targets were compared in treated and placebo groups as secondary endpoints. In the treatment group the 6MWT improved at 3 (from 210±104 mt to 225±94 mt; P=0.033) but not at 6 months (from 210±104 mt to 217±94 mt; P=0.288) while PTH dropped at 3 (from 76.8±50.5 to 50.2±20.3 pg/mL; P=0.025), but not at 6 months. 6MWT improvement was negatively related to baseline VD levels. Variation in 6MWT did not significantly differ among groups at 3 (13.6±23.3 vs. 3.6±17.3; P 0.175) and 6 months (12.1±31.4 vs. 0.2±23.2; P 0.225). Left atrial size increased in the placebo group (from 50.8±20.7 to 61.7±36.0 mL/m2; P=0.010). Other hormonal parameters remained unchanged.
Conclusions
In summary, the treatment of VD deficiency in patients with HF improved 6MWT after 3 months along with a decrease in PTH levels. However when compared with the placebo arm, treatment of VD deficiency did not influence the final outcomes.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.