Effect of age, diet, and tissue type on PCr response to creatine supplementation
Solis MY, Artioli GG, Otaduy MCG, Leite CDC, Arruda W, Veiga RR, Gualano B
Journal of applied physiology (Bethesda, Md. : 1985) · 42 citas
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- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Gobierno
- São Paulo Research Foundation (FAPESP)
- Subvenciones
- Fundação de Amparo à Pesquisa do Estado de São Paulo (2014/06911-9)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2017-06-01 · J Appl Physiol (1985) · vol. 123 · número 2 · págs. 407–414
- Editorial
- American Physiological Society
- Citado
- 69 citas · más que el 82% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 52 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Muscle metabolism and nutrition · Obesity, Physical Activity, Diet · Sports Performance and Training
- Palabras clave
- Creatine, Phosphocreatine, Internal medicine, Omnivore, Creatine kinase, Endocrinology, Muscle tissue, Placebo, Medicine, Biology, Physiology, Energy metabolism, Pathology
- MeSH
- muscle, skeletal, brain, humans, creatine, phosphocreatine, magnetic resonance spectroscopy, diet, single-blind method, dietary supplements, adult, aged, child, female, male
7 autores
- Marina Yázigi Solis🇧🇷Universidade de São Paulo
- Guilherme Giannini Artioli🇧🇷🇬🇧Universidade de São Paulo; Nottingham Trent University
- Maria Concepción García Otaduy🇧🇷Universidade de São Paulo
- Cláudia da Costa Leite🇧🇷Universidade de São Paulo
- Walquiria Arruda🇧🇷Centro Universitário das Faculdades Metropolitanas Unidas
- Raquel Ramos Veiga🇧🇷Centro Universitário das Faculdades Metropolitanas Unidas
- Bruno Gualano🇧🇷 · autor de correspondenciaUniversidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Creatine/phosphorylcreatine (PCr) responses to creatine supplementation may be modulated by age, diet, and tissue, but studies assessing this possibility are lacking. Therefore we aimed to determine whether PCr responses vary as a function of age, diet, and tissue. Fifteen children, 17 omnivorous and 14 vegetarian adults, and 18 elderly individuals ("elderly") participated in this study. Participants were given placebo and subsequently creatine (0.3 g·kg-1·day-1) for 7 days in a single-blind fashion. PCr was measured through phosphorus magnetic resonance spectroscopy (31P-MRS) in muscle and brain. Creatine supplementation increased muscle PCr in children (P P P = 0.3348). Elderly had greater PCr increases than children and omnivores (P P = 0.0022). In relation to diet, vegetarians (P P -1·day-1 for 7 days) may be affected by age, diet, and tissue. Whereas creatine supplementation was able to increase muscle PCr in all groups, although to different extents, brain PCr was shown to be unresponsive overall. These findings demonstrate the need to tailor creatine protocols to optimize creatine/PCr accumulation both in muscle and in brain, enabling a better appreciation of the pleiotropic properties of creatine.NEW & NOTEWORTHY A standardized creatine supplementation protocol (0.3 g·kg-1·day-1 for 7 days) effectively increased muscle, but not brain, phosphorylcreatine. Older participants responded better than younger participants whereas vegetarians responded better than omnivores. Responses to supplementation are thus dependent on age, tissue, and diet. This suggests that a single "universal" protocol, originally designed for increasing muscle creatine in young individuals, may lead to heterogeneous muscle responses in different populations or even no responses in tissues other than skeletal muscle.
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