The effectiveness of creatine treatment for Parkinson's disease: an updated meta-analysis of randomized controlled trials
Mo JJ, Liu LY, Peng WB, Rao J, Liu Z, Cui LL
BMC neurology · 19 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Natural Science Foundation of Guangdong Province
- Gobierno
- Science and Technology Planning Project of Zhanjiang
- Gobierno
- Project of Dongguan
- Subvenciones
- Natural Science Foundation of Guangdong Province (2014A030313541); National Natural Science Foundation of China (81400986)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-06-02 · BMC Neurol · vol. 17 · número 1 · pág. 105
- Editorial
- BioMed Central
- Citado
- 31 citas · más que el 27% de estudios similares · 0.2× el promedio de su campo
- Referencias
- 31 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · Parkinson's Disease Mechanisms and Treatments · Nutrition and Health in Aging
- Palabras clave
- Medicine, Meta-analysis, Neurochemistry, Neurology, Randomized controlled trial, Parkinson's disease, Neurosurgery, Creatine, Physical therapy, Disease, Internal medicine, Physical medicine and rehabilitation, Intensive care medicine, Surgery, Psychiatry
- MeSH
- humans, parkinson disease, creatine, treatment outcome, activities of daily living, randomized controlled trials as topic
6 autores
- Jiajie Mo🇨🇳Guangdong Medical College
- Lin-Ying Liu🇨🇳Chenzhou First People's Hospital
- Wei-Bin Peng🇨🇳Guangzhou Medical University
- Jie Rao🇨🇳Wuhan University; Renmin Hospital of Wuhan University
- Zhou Liu🇨🇳 · autor de correspondenciaGuangdong Medical College
- Lili Cui🇨🇳 · autor de correspondenciaGuangdong Medical College
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The effectiveness of creatine in treating Parkinson's disease (PD) has not been conclusively determined. Therefore, we performed a meta-analysis to address this issue.
Methods
The Cochrane Central Register of Controlled Trials, PUBMED, EMBASE, and other databases were searched, and outcomes measured by the Total Unified Parkinson's Disease Rating Scale (UPDRS) and the Schwab & England Scale were analyzed.
Results
Five randomized controlled trials (RCTs) were selected, and 1339 participants were included in the analysis. There were no significant differences between the control and treatment groups in the total, mental, activities of daily living (ADL), or motor UPDRS scores, but an improvement in Schwab & England Scale scores was observed.
Conclusions
Creatine has no observed benefit in PD patients, although more correlated studies are still needed.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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