Coffee and caffeine intake and male infertility: a systematic review
Ricci E, Viganò P, Cipriani S, Somigliana E, Chiaffarino F, Bulfoni A, Parazzini F
Nutrition journal · 78 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-06-24 · Nutr J · vol. 16 · número 1 · pág. 37
- Editorial
- BioMed Central
- Citado
- 157 citas · más que el 90% de estudios similares · 2.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 63 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Sperm and Testicular Function · Coffee research and impacts · Hormonal and reproductive studies
- Palabras clave
- Caffeine, Sperm, Medicine, Semen, Fertility, Male infertility, Semen quality, Semen analysis, Infertility, Physiology, Observational study, Reproductive medicine, Gynecology, Pregnancy, Andrology, Biology, Internal medicine, Population, Environmental health, Genetics
- MeSH
- spermatozoa, humans, infertility, male, dna damage, caffeine, sperm count, sperm motility, fertility, carbonated beverages, coffee, male, semen analysis, observational studies as topic
7 autores
- Elena Delfina Ricci🇮🇹 · autor de correspondenciaFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Paola Viganò🇮🇹IRCCS Ospedale San Raffaele
- Sonia Cipriani🇮🇹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Edgardo Somigliana🇮🇹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Francesça Chiaffarino🇮🇹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Alessandro Bulfoni🇮🇹IRCCS Humanitas Research Hospital
- Fabio Parazzini🇮🇹University of Milan; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Semen quality, a predictor of male fertility, has been suggested declining worldwide. Among other life style factors, male coffee/caffeine consumption was hypothesized to influence semen parameters, but also sperm DNA integrity. To summarize available evidence, we performed a systematic review of observational studies on the relation between coffee/caffeine intake and parameters of male fertility including sperm ploidy, sperm DNA integrity, semen quality and time to pregnancy.
Methods
A systematic literature search was performed up to November 2016 (MEDLINE and EMBASE). We included all observational papers that reported the relation between male coffee/caffeine intake and reproductive outcomes: 1. semen parameters, 2. sperm DNA characteristics, 3. fecundability. All pertinent reports were retrieved and the relative reference lists were systematically searched in order to identify any potential additional studies that could be included.
Results
We retrieved 28 papers reporting observational information on coffee/caffeine intake and reproductive outcomes. Overall, they included 19,967 men. 1. Semen parameters did not seem affected by caffeine intake, at least caffeine from coffee, tea and cocoa drinks, in most studies. Conversely, other contributions suggested a negative effect of cola-containing beverages and caffeine-containing soft drinks on semen volume, count and concentration. 2. As regards sperm DNA defects, caffeine intake seemed associated with aneuploidy and DNA breaks, but not with other markers of DNA damage. 3. Finally, male coffee drinking was associated to prolonged time to pregnancy in some, but not all, studies.
Conclusions
The literature suggests that caffeine intake, possibly through sperm DNA damage, may negatively affect male reproductive function. Evidence from epidemiological studies on semen parameters and fertility is however inconsistent and inconclusive. Well-designed studies with predefined criteria for semen analysis, subject selection, and life style habits definition, are essential to reach a consistent evidence on the effect of caffeine on semen parameters and male fertility.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.