A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD
Kumar V, Yadav AK, Lal A, Kumar V, Singhal M, Billot L, Gupta KL, Banerjee D, Jha V
Journal of the American Society of Nephrology : JASN · 91 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- British Heart Foundation
- Subvenciones
- British Heart Foundation (PG/10/71/28462)
Según 1 financiador declarado.
Publicación
- Publicado
- 2017-06-30 · J Am Soc Nephrol · vol. 28 · número 10 · págs. 3100–3108
- Editorial
- American Society of Nephrology
- Citado
- 122 citas · más que el 99% de estudios similares · 12.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 37 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Cardiovascular Health and Disease Prevention · Parathyroid Disorders and Treatments
- Palabras clave
- vitamin D supplementation, vitamin D3, vitamin D deficiency, chronic kidney disease, vascular function, endothelial function, flow-mediated dilation, pulse wave velocity, interleukin-6, cardiovascular risk
- MeSH
- endothelium, vascular, humans, cardiovascular diseases, vitamins, vitamin d, c-reactive protein, interleukin-6, vasodilation, dietary supplements, adult, middle aged, female, male, renal insufficiency, chronic, vascular stiffness, pulse wave analysis, biomarkers
9 autores
- Vivek Kumar · autor de correspondencia
- Ashok Kumar Yadav · autor de correspondencia
- Anupam Lal🇮🇳Post Graduate Institute of Medical Education and Research
- Vinod Kumar · autor de correspondencia
- Manphool Singhal🇮🇳Post Graduate Institute of Medical Education and Research
- Laurent Billot🇦🇺The University of Sydney; The George Institute for Global Health
- Krishan Lal Gupta · autor de correspondencia
- Debasish Banerjee🇬🇧National Health Service; St George's, University of London; St George’s University Hospitals NHS Foundation Trust
- Vivekanand Jha🇬🇧🇮🇳 · autor de correspondenciaThe George Institute for Global Health; University of Oxford; George Institute for Global Health; Post Graduate Institute of Medical Education and Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Vitamin D deficiency associates with mortality in patients with CKD, and vitamin D supplementation might mitigate cardiovascular disease risk in CKD. In this randomized, double-blind, placebo-controlled trial, we investigated the effect of cholecalciferol supplementation on vascular function in 120 patients of either sex, aged 18-70 years, with nondiabetic CKD stage 3-4 and vitamin D deficiency (serum 25-hydroxyvitamin D ≤20 ng/ml). We randomized patients using a 1:1 ratio to receive either two directly observed oral doses of cholecalciferol (300,000 IU) or matching placebo at baseline and 8 weeks. The primary outcome was change in endothelium-dependent brachial artery flow-mediated dilation at 16 weeks. Secondary outcome measures included changes in pulse wave velocity and circulating biomarkers. Cholecalciferol supplementation significantly increased endothelium-dependent brachial artery flow-mediated dilation at 16 weeks, whereas placebo did not (between-group difference in mean change: 5.49%; 95% confidence interval, 4.34% to 6.64%; P<0.001). Intervention also led to significant favorable changes in pulse wave velocity and circulating IL-6 levels. Thus, in nondiabetic patients with stage 3-4 CKD and vitamin D deficiency, vitamin D supplementation may improve vascular function. This study is registered with the Clinical Trials Registry of India (no.: CTRI/2013/05/003648).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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