Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data
Rejnmark L, Bislev LS, Cashman KD, Eiríksdottir G, Gaksch M, Grübler M, Grimnes G, Gudnason V, Lips P, Pilz S, van Schoor NM, Kiely M, Jorde R
PloS one · 161 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- European Commission
- Subvenciones
- European Commission (613977)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-07-07 · PLoS One · vol. 12 · número 7 · pág. e0180512
- Editorial
- Public Library of Science
- Citado
- 235 citas · más que el 99% de estudios similares · 7.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 321 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health Studies · Nutritional Studies and Diet
- Palabras clave
- vitamin D supplementation, 25-hydroxyvitamin D, cardiovascular disease, type 2 diabetes, weight loss, mortality, depression, blood pressure, respiratory infections, trial design characteristics
- MeSH
- humans, neoplasms, cardiovascular diseases, diabetes mellitus, type 2, weight loss, vitamin d, nutrition therapy, risk factors, dietary supplements, randomized controlled trials as topic
13 autores
- Lars Rejnmark🇩🇰 · autor de correspondenciaAarhus University Hospital
- Lise Sofie Bislev🇩🇰Aarhus University Hospital
- Kevin D. Cashman🇮🇪University College Cork
- Guðný Eiríksdóttir🇮🇸Icelandic Heart Association
- Martin Gaksch🇦🇹Medical University of Graz
- Martin Robert Grübler🇨🇭🇦🇹University of Bern; Medical University of Graz; University Hospital of Bern
- Guri Grimnes🇳🇴UiT The Arctic University of Norway
- Vilmundur G. Gudnason🇮🇸University of Iceland; Icelandic Heart Association
- Paul T.A.M. Lips🇳🇱Vrije Universiteit Amsterdam; Amsterdam UMC Location Vrije Universiteit Amsterdam
- Stefan Pilz🇦🇹Medical University of Graz
- Natasja M. van Schoor🇳🇱Amsterdam Public Health; Amsterdam UMC Location Vrije Universiteit Amsterdam
- Mairead E Kiely🇮🇪University College Cork
- Rolf Jorde🇳🇴UiT The Arctic University of Norway
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
A large number of observational studies have reported harmful effects of low 25-hydroxyvitamin D (25OHD) levels on non-skeletal outcomes. We performed a systematic quantitative review on characteristics of randomized clinical trials (RCTs) included in meta-analyses (MAs) on non-skeletal effects of vitamin D supplementation.
Methods and findings
We identified systematic reviews (SR) reporting summary data in terms of MAs of RCTs on selected non-skeletal outcomes. For each outcome, we summarized the results from available SRs and scrutinized included RCTs for a number of predefined characteristics. We identified 54 SRs including data from 210 RCTs. Most MAs as well as the individual RCTs reported null-findings on risk of cardiovascular diseases, type 2 diabetes, weight-loss, and malignant diseases. Beneficial effects of vitamin D supplementation was reported in 1 of 4 MAs on depression, 2 of 9 MAs on blood pressure, 3 of 7 MAs on respiratory tract infections, and 8 of 12 MAs on mortality. Most RCTs have primarily been performed to determine skeletal outcomes, whereas non-skeletal effects have been assessed as secondary outcomes. Only one-third of the RCTs had low level of 25OHD as a criterion for inclusion and a mean baseline 25OHD level below 50 nmol/L was only present in less than half of the analyses.
Conclusions
Published RCTs have mostly been performed in populations without low 25OHD levels. The fact that most MAs on results from RCTs did not show a beneficial effect does not disprove the hypothesis suggested by observational findings on adverse health outcomes of low 25OHD levels.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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