Chemopreventive effects of a Tamarindus indica fruit extract against colon carcinogenesis depends on the dietary cholesterol levels in hamsters
Martinello F, Kannen V, Franco JJ, Gasparotto B, Sakita JY, Sugohara A, Garcia SB, Uyemura SA
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 8 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Subvenciones
- Fundação de Amparo à Pesquisa do Estado de São Paulo (02/03174-5); Conselho Nacional de Desenvolvimento Científico e Tecnológico (475276/01-9)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2017-07-04 · Food Chem Toxicol · vol. 107 · número Pt A · págs. 261–269
- Editorial
- Elsevier BV
- Citado
- 17 citas · más que el 62% de estudios similares · 2.0× el promedio de su campo
- Referencias
- 57 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Cancer, Lipids, and Metabolism · Genetic factors in colorectal cancer · Pharmacological Effects of Medicinal Plants
- Palabras clave
- TBARS, Lipid peroxidation, Thiobarbituric acid, Carcinogen, Chemoprotective, Glutathione peroxidase, Antioxidant, Superoxide dismutase, Triglyceride, Alanine transaminase, Chemistry, Cholesterol, Aspartate transaminase, Biochemistry, Hamster, Azoxymethane, Aberrant crypt foci, 1,2-Dimethylhydrazine, Colorectal cancer, Food science, Internal medicine, Biology, Endocrinology, Carcinogenesis, Cancer, Medicine, Enzyme, Alkaline phosphatase
- MeSH
- colon, liver, animals, humans, mesocricetus, tamarindus, fruit, colonic neoplasms, thiobarbituric acid reactive substances, 1,2-dimethylhydrazine, cholesterol, dietary, plant extracts, anticarcinogenic agents, carcinogens, lipid peroxidation, cricetinae, male
8 autores
- Flávia Martinello🇧🇷Universidade Federal de Santa Catarina
- Vinicius Kannen🇧🇷 · autor de correspondenciaUniversidade de São Paulo
- João José Franco🇧🇷Universidade de São Paulo
- Bianca Gasparotto🇧🇷Universidade de São Paulo
- Juliana Yumi Sakita🇧🇷Universidade de São Paulo
- Atushi Sugohara🇧🇷Universidade Estadual Paulista (Unesp)
- Sérgio Britto Garcia🇧🇷Universidade de São Paulo
- Sérgio Akira Uyemura🇧🇷Universidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Tamarind has significant antioxidant potential. We showed that tamarind protects hypercholesterolemic hamsters from atherosclerosis. Hypercholesterolemia might increase the risk of colon cancer. We investigated whether tamarind extract modulates the risk of colon cancer in hypercholesterolemic hamsters. Hamsters (n = 64) were given tamarind and a hypercholesterolemic diet for 8 weeks. The groups were the control, tamarind treatment, hypercholesterolemic, and hypercholesterolemic treated with tamarind groups. Half of each group was exposed to the carcinogen dimethylhydrazine (DMH) at the 8th week. All hamsters were euthanatized at the 10th week. In carcinogen-exposed hypercholesterolemic hamsters, tamarind did not alter the cholesterol or triglyceride serum levels, but it reduced biomarkers of liver damage (alanine transaminase [ALT], and aspartate aminotransferase [AST]). Tamarind decreased DNA damage in hepatocytes, as demonstrated by analysis with an anti-γH2A.X antibody. In liver and serum samples, we found that this fruit extract reduced lipid peroxidation (thiobarbituric acid reactive substances [TBARS]) and increased endogenous antioxidant mechanisms (glutathione peroxidase [GPx] and superoxide dismutase [SOD]). However, tamarind did not alter either lipid peroxidation or antioxidant defenses in the colon, which contrasts with DMH exposure. Moreover, tamarind significantly increased the stool content of cholesterol. Although tamarind reduced the risk of colon cancer in hypercholesterolemic hamsters that were carcinogenically exposed to DMH by 63.8% (Metallothionein), it was still ∼51% higher than for animals fed a regular diet. Staining colon samples with an anti-γH2A.X antibody confirmed these findings. We suggest that tamarind has chemoprotective activity against the development of colon carcinogenesis, although a hypercholesterolemic diet might impair this protection.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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