Financiado en parte por Symrise
Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells
Liszt KI, Ley JP, Lieder B, Behrens M, Stöger V, Reiner A, Hochkogler CM, Köck E, Marchiori A, Hans J, Widder S, Krammer G, Sanger GJ, Somoza MM, Meyerhof W, Somoza V
Proceedings of the National Academy of Sciences of the United States of America · 105 citas
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Cómo se estudió
- Diseño
- Estudio in vitro o de mecanismos (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- Österreichische Nationalstiftung für Forschung, Technologie und Entwicklung
- Gobierno
- Austrian Federal Ministry of Economy, Family and Youth
- Gobierno
- Institut National de la Santé et de la Recherche Médicale
- Gobierno
- Austrian Science Fund
- Empresa
- Symrise
- Gobierno
- Biotechnology and Biological Sciences Research Council
- Gobierno
- Austrian Science Fund FWF
- Gobierno
- Medical Research Council
- Subvenciones
- Austrian Science Fund (FWF P23797); Austrian Science Fund (P23797); Biotechnology and Biological Sciences Research Council (1507481)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2017-07-10 · Proc Natl Acad Sci U S A · vol. 114 · número 30 · págs. E6260–E6269
- Editorial
- National Academy of Sciences
- Citado
- 139 citas · más que el 98% de estudios similares · 7.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Biochemical Analysis and Sensing Techniques · Olfactory and Sensory Function Studies · Advanced Chemical Sensor Technologies
- Palabras clave
- Gastric acid, Caffeine, Secretion, Taste, Bitter taste, Parietal cell, Gastric mucosa, Peptic ulcer, Internal medicine, Chemistry, Medicine, Pharmacology, Stomach, Biochemistry
- MeSH
- parietal cells, gastric, gastric acid, humans, flavones, caffeine, receptors, g-protein-coupled, taste
16 autores
- Kathrin Ingrid Liszt🇦🇹University of Vienna; Christian Doppler Laboratory for Thermoelectricity
- Jakob Peter Ley🇩🇪Symrise (Germany)
- Barbara Lieder🇦🇹University of Vienna; Christian Doppler Laboratory for Thermoelectricity
- Maik Behrens🇩🇪German Institute of Human Nutrition
- Verena Stöger🇦🇹Christian Doppler Laboratory for Thermoelectricity
- Angelika Reiner🇦🇹Donauspital
- Christina Maria Hochkogler🇦🇹Christian Doppler Laboratory for Thermoelectricity
- Elke Köck🇦🇹University of Vienna
- Alessandro Marchiori🇩🇪German Institute of Human Nutrition
- Joachim Hans🇩🇪Symrise (Germany)
- Sabine Widder🇩🇪Symrise (Germany)
- Gerhard E. Krammer🇩🇪Symrise (Germany)
- Gareth John Sanger
- Mark Manuel Somoza🇦🇹University of Vienna
- Wolfgang Meyerhof🇩🇪German Institute of Human Nutrition
- Veronika Somoza🇦🇹 · autor de correspondenciaUniversity of Vienna; Christian Doppler Laboratory for Thermoelectricity
Resumen
El texto original del estudio, en el idioma en que se publicó.
Caffeine, generally known as a stimulant of gastric acid secretion (GAS), is a bitter-tasting compound that activates several taste type 2 bitter receptors (TAS2Rs). TAS2Rs are expressed in the mouth and in several extraoral sites, e.g., in the gastrointestinal tract, in which their functional role still needs to be clarified. We hypothesized that caffeine evokes effects on GAS by activation of oral and gastric TAS2Rs and demonstrate that caffeine, when administered encapsulated, stimulates GAS, whereas oral administration of a caffeine solution delays GAS in healthy human subjects. Correlation analysis of data obtained from ingestion of the caffeine solution revealed an association between the magnitude of the GAS response and the perceived bitterness, suggesting a functional role of oral TAS2Rs in GAS. Expression of TAS2Rs, including cognate TAS2Rs for caffeine, was shown in human gastric epithelial cells of the corpus/fundus and in HGT-1 cells, a model for the study of GAS. In HGT-1 cells, various bitter compounds as well as caffeine stimulated proton secretion, whereby the caffeine-evoked effect was (i) shown to depend on one of its cognate receptor, TAS2R43, and adenylyl cyclase; and (ii) reduced by homoeriodictyol (HED), a known inhibitor of caffeine's bitter taste. This inhibitory effect of HED on caffeine-induced GAS was verified in healthy human subjects. These findings (i) demonstrate that bitter taste receptors in the stomach and the oral cavity are involved in the regulation of GAS and (ii) suggest that bitter tastants and bitter-masking compounds could be potentially useful therapeutics to regulate gastric pH.
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