Comparison Of Lipid Lowering Effect Of Extra Virgin Olive Oil And Atorvastatin In Dyslipidaemia In Type 2 Diabetes Mellitus
Khan TM, Iqbal S, Rashid MA
Journal of Ayub Medical College, Abbottabad : JAMC · 4 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
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- Resultado principal
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- Consumo medido con
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Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2019-04-16 · J Ayub Med Coll Abbottabad · vol. 29 · número 1 · págs. 83–86
- Editorial
- National Institutes of Health
- Citado
- 9 citas · más que el 81% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 10 trabajos
- Acceso
- De pago
- Áreas de investigación
- Lipoproteins and Cardiovascular Health · Natural Products and Biological Research · Edible Oils Quality and Analysis
- Palabras clave
- extra virgin olive oil, atorvastatin, type 2 diabetes, dyslipidemia, lipid lowering, plasma lipids, HDL cholesterol, monounsaturated fatty acids, antioxidants, lipid-lowering drugs
- MeSH
- humans, diabetes mellitus, type 2, lipids, hyperlipidemias, hypolipidemic agents, olive oil, atorvastatin
3 autores
- Tariq Mahmood Khan🇵🇰Frontier Medical College
- Sohail Iqbal🇵🇰Mohtarma Benazir Bhutto Shaheed Medical College
- Muhammad Adnan Rashid🇵🇰Ayub Medical College
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Extra virgin olive oil (EVOO) is fruit oil with rich source of monounsaturated fats and powerful antioxidants. It acts as hypolipidemic agent and significant decrease of plasma lipids level was observed with EVOO use. Atorvastatin is hypolipidemic drug commonly used for treatment of hyperlipidaemia. The purpose of this study was to determine & compare the lipid lowering effect of EVOO with atorvastatin in type 2 diabetic dyslipidaemia which is leading cause of microvascular diseases.
Methods
This randomised controlled trial was conducted on 60 already diagnosed cases of type 2 diabetes mellitus with dyslipidaemia. All sixty subjects were divided randomly into 2 groups. Atorvastatin 40 mg was given to Group One and two tablespoons of extra virgin olive oil orally per day was given to Group Two. Blood was collected for estimation of plasma lipids level at base line, 4th week, and 6th weeks in two groups and was compared statistically.
Results
The present study demonstrated 20-40% lipid lowering effect of atorvastatin on plasma lipids level with 9-16% increase in HDL while extra virgin olive oil showed 14-25% reduction in plasma lipids with 8-12% increase in HDL-cholesterol level.
Conclusions
This study concludes that both atorvastatin and extra virgin olive oil are effective in reducing plasma lipids level in type 2 diabetic dyslipidaemia with more prominent effect of atorvastatin than EVOO.
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