Dietary linoleic acid intake and blood inflammatory markers: a systematic review and meta-analysis of randomized controlled trials
Su H, Liu R, Chang M, Huang J, Wang X
Food & function · 43 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2017-01-01 · Food Funct · vol. 8 · número 9 · págs. 3091–3103
- Editorial
- Royal Society of Chemistry
- Citado
- 52 citas · más que el 52% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 87 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Inflammatory mediators and NSAID effects
- Palabras clave
- dietary linoleic acid, omega-6 fatty acids, inflammatory markers, C-reactive protein, cytokines, interleukin-6, TNF-α, adiponectin, MCP-1, acute phase proteins, fibrinogen, plasminogen activator inhibitor-1, adhesion molecules, dietary supplementation, dose-response relationship
- MeSH
- humans, inflammation, linoleic acids, c-reactive protein, diet, dietary supplements, randomized controlled trials as topic, biomarkers
5 autores
- Hang Su🇨🇳Jiangnan University; State Key Laboratory of Food Science and Technology
- Ruijie Liu🇨🇳Jiangnan University; State Key Laboratory of Food Science and Technology
- Ming Chang🇨🇳Jiangnan University; State Key Laboratory of Food Science and Technology
- Jianhua Huang🇨🇳Jiangnan University; State Key Laboratory of Food Science and Technology
- Xingguo Wang🇨🇳 · autor de correspondenciaJiangnan University; State Key Laboratory of Food Science and Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
The aim of the present study was to investigate the effect of increasing dietary linoleic acid (LA) intake on the blood concentrations of inflammatory markers including cytokines, acute phase reactants and adhesion molecules in adults.
Methods
We comprehensively searched PubMed, Embase and Cochrane Library for eligible studies. Overall, 30 randomized controlled studies involving 1377 subjects were included for meta-analysis.
Results
No significant effect of higher LA intake was observed for cytokines: tumor necrosis factor (SMD: -0.01; 95% CI: -0.19 to 0.17), interleukin-6 (SMD: 0.11, 95% CI: -0.07 to 0.29), adiponectin (SMD: 0.17, 95% CI: -0.17 to 0.50) and monocyte chemoattractant protein 1 (SMD: 0.14, 95% CI: -0.33 to 0.60). Pooled effect size from 16 studies showed that the C-reactive protein (CRP) concentration was not significantly affected by increasing LA intake (SMD = 0.09, 95% CI: -0.05 to 0.24). However, subgroup and meta-regression analysis suggested that in subjects with a more profound increase of dietary LA intake, LA might increase the blood CRP level. Other acute phase reactants including fibrinogen and plasminogen activator inhibitor-1 and adhesion molecules were not significantly changed when LA was increased in diet. No significant heterogeneity or publication bias was observed, although only a limited number of eligible studies were included for some markers.
Conclusion
Our meta-analysis suggested that increasing dietary LA intake does not have a significant effect on the blood concentrations of inflammatory markers. However, the extent of change in dietary LA intake might affect the effect of LA supplementation on CRP.
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