Whole Grain Intake and Glycaemic Control in Healthy Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Marventano S, Vetrani C, Vitale M, Godos J, Riccardi G, Grosso G
Nutrients · 84 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-07-19 · Nutrients · vol. 9 · número 7 · pág. 769
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 119 citas · más que el 86% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 67 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Celiac Disease Research and Management
- Palabras clave
- Postprandial, Medicine, Insulin, Randomized controlled trial, Insulin resistance, Meta-analysis, Glucose homeostasis, Observational study, Homeostatic model assessment, Internal medicine, Endocrinology
- MeSH
- humans, insulin resistance, insulin, blood glucose, diet, postprandial period, randomized controlled trials as topic, whole grains
6 autores
- Stefano Marventano🇮🇹University of Catania
- Claudia Vetrani🇮🇹Federico II University Hospital
- Marilena Vitale🇮🇹 · autor de correspondenciaFederico II University Hospital
- Justyna Godos🇮🇹Azienda Ospedaliero Universitaria Policlinico "G.Rodolico - San Marco"
- Gabriele Riccardi🇮🇹Federico II University Hospital
- Giuseppe Grosso🇮🇹Azienda Ospedaliero Universitaria Policlinico "G.Rodolico - San Marco"
Resumen
El texto original del estudio, en el idioma en que se publicó.
Backgrounds
There is growing evidence from both observational and intervention studies that Whole Grain (WG) cereals exert beneficial effects on human health, especially on the metabolic profile. The aim of this study was to perform a meta-analysis of randomised controlled trials (RCT) to assess the acute and medium/long-term effect of WG foods on glycaemic control and insulin sensitivity in healthy individuals.
Methods
A search for all the published RCT on the effect of WG food intake on glycaemic and insulin response was performed up to December 2016. Effect size consisted of mean difference (MD) and 95% CI between the outcomes of intervention and the control groups using the generic inverse-variance random effects model.
Results
The meta-analysis of the 14 studies testing the acute effects of WG foods showed significant reductions of the post-prandial values of the glucose iAUC (0-120 min) by -29.71 mmol min/L (95% CI: -43.57, -15.85 mmol min/L), the insulin iAUC (0-120 min) by -2.01 nmol min/L (95% CI: -2.88, -1.14 nmol min/L), and the maximal glucose and insulin response. In 16 medium- and long-term RCTs, effects of WG foods on fasting glucose and insulin and homeostatic model assessment-insulin resistance values were not significant.
Conclusions
The consumption of WG foods is able to improve acutely the postprandial glucose and insulin homeostasis compared to similar refined foods in healthy subjects. Further research is needed to better understand the long-term effects and the biological mechanisms.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.