A Systematic Review and Meta-Analysis of The Effect of Low Vitamin D on Cognition
Goodwill AM, Szoeke C
Journal of the American Geriatrics Society · 128 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Alzheimer's Association
- Organización sin fines de lucro
- Brain Foundation
- Gobierno
- National Health and Medical Research Council
- Organización sin fines de lucro
- Alzheimer's Association
- Subvenciones
- National Health and Medical Research Council (1032350); National Health and Medical Research Council (1062133); National Health and Medical Research Council (547600); Alzheimer's Association (NIA320312)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2017-07-31 · J Am Geriatr Soc · vol. 65 · número 10 · págs. 2161–2168
- Editorial
- Wiley
- Citado
- 180 citas · más que el 95% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Dementia and Cognitive Impairment Research · Nutritional Studies and Diet
- Palabras clave
- vitamin D, vitamin D deficiency, vitamin D supplementation, cognition, cognitive decline, dementia risk, older adults, middle-aged adults, aging, risk factor control
- MeSH
- humans, vitamin d deficiency, vitamins, vitamin d, longitudinal studies, cross-sectional studies, cognition, dietary supplements, adult, aged, middle aged, female, male, observational studies as topic, cognitive dysfunction
2 autores
- Alicia M. Goodwill🇦🇺 · autor de correspondenciaAustralian Catholic University
- Cassandra E. I. Szoeke🇦🇺The Royal Melbourne Hospital; The University of Melbourne; Australian Catholic University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/objective
With an aging population and no cure for dementia on the horizon, risk factor modification prior to disease onset is an urgent health priority. Therefore, this review examined the effect of low vitamin D status or vitamin D supplementation on cognition in midlife and older adults without a diagnosis of dementia.
Design
Systematic review and random effect meta-analysis.
Setting
Observational (cross-sectional and longitudinal cohort) studies comparing low and high vitamin D status and interventions comparing vitamin D supplementation with a control group were included in the review and meta-analysis.
Participants
Studies including adults and older adults without a dementia diagnosis were included.
Measurements
Medline (PubMed), AMED, Psych INFO, and Cochrane Central databases were searched for articles until August 2016. The Newcastle-Ottawa Scale and Physiotherapy Evidence Database assessed methodological quality of all studies.
Results
Twenty-six observational and three intervention studies (n = 19-9,556) were included in the meta-analysis. Low vitamin D was associated with worse cognitive performance (OR = 1.24, CI = 1.14-1.35) and cognitive decline (OR = 1.26, CI = 1.09-1.23); with cross-sectional yielding a stronger effect compared to longitudinal studies. Vitamin D supplementation showed no significant benefit on cognition compared with control (SMD = 0.21, CI = -0.05 to 0.46).
Conclusion
Observational evidence demonstrates low vitamin D is related to poorer cognition; however, interventional studies are yet to show a clear benefit from vitamin D supplementation. From the evidence to date, there is likely a therapeutic age window relevant to the development of disease and therefore vitamin D therapy. Longitudinal lifespan studies are necessary to depict the optimal timing and duration in which repletion of vitamin D may protect against cognitive decline and dementia in aging, to better inform trials and practice towards a successful therapy.
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