Financiado en parte por American Music Therapy Association
Effects of Improvisational Music Therapy vs Enhanced Standard Care on Symptom Severity Among Children With Autism Spectrum Disorder: The TIME-A Randomized Clinical Trial
Bieleninik L, Geretsegger M, Mössler K, Assmus J, Thompson G, Gattino G, Elefant C, Gottfried T, Igliozzi R, Muratori F, Suvini F, Kim J, Crawford MJ, Odell-Miller H, Oldfield A, Casey Ó, Finnemann J, Carpente J, Park AL, Grossi E, Gold C, TIME-A Study Team
JAMA · 77 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- American Music Therapy Association
- Gobierno
- National Institute for Health and Care Research
- Universidad u hospital
- University of Melbourne
- Universidad u hospital
- Jeonju University
- Universidad u hospital
- Aalborg Universitet
- Universidad u hospital
- Universität Wien
- Universidad u hospital
- Hospital de Clínicas de Porto Alegre
- Gobierno
- Helse Vest
- Organización sin fines de lucro
- Danmarks Frie Forskningsfond
- Universidad u hospital
- Universitetet i Bergen
- Gobierno
- Norges Forskningsråd
- Organización sin fines de lucro
- Fundação Instituto de Pesquisas Econômicas
- Universidad u hospital
- Università di Pisa
- Gobierno
- Health Technology Assessment Programme
- Gobierno
- National Institute for Health Research (NIHR)
- Subvenciones
- National Institute for Health and Care Research (12/167/95); Helse Vest (911800); Health Technology Assessment Programme (12/167/95); Norges Forskningsråd (213844)
Según 15 financiadores declarados.
Publicación
- Publicado
- 2017-08-08 · JAMA · vol. 318 · número 6 · pág. 525
- Editorial
- American Medical Association
- Citado
- 197 citas · más que el 98% de estudios similares · 8.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Autism Spectrum Disorder Research · Family and Disability Support Research · Music Therapy and Health
- Palabras clave
- Medicine, Music therapy, Autism spectrum disorder, Improvisation, Autism, Audiology, Physical therapy, Psychiatry
- MeSH
- humans, treatment outcome, music therapy, single-blind method, attention, child, child, preschool, female, male, social skills, autism spectrum disorder
22 autores
- Łucja Bieleninik🇳🇴Uni Research (Norway)
- Monika Geretsegger🇳🇴Uni Research (Norway)
- Karin Antonia Mössler🇳🇴Uni Research (Norway)
- Jörg Aßmus🇳🇴Uni Research (Norway)
- Grace Anne Thompson🇦🇺The University of Melbourne
- Gustavo Gattino🇧🇷🇩🇰Universidade Federal do Rio Grande do Sul; Aalborg University
- Cochavit Elefant🇮🇱University of Haifa
- Tali Gottfried🇮🇱David Yellin College of Education
- Roberta Igliozzi🇮🇹Fondazione Stella Maris
- Filippo Muratori🇮🇹University of Pisa; Fondazione Stella Maris
- Ferdinando Suvini🇮🇹Fondazione Stella Maris
- Jinah Kim🇰🇷Jeonju University
- Mike Crawford🇬🇧Imperial College London
- Helen Odell‐Miller🇬🇧Anglia Ruskin University
- Amelia Oldfield🇬🇧Anglia Ruskin University
- Orla M. Casey🇬🇧Anglia Ruskin University
- Johanna Finnemann🇬🇧University of Cambridge; Anglia Ruskin University
- John Carpente🇺🇸Molloy College; Perfect Harmony Health
- A‐La Park🇬🇧London School of Economics and Political Science
- Enzo Grossi
- Christian Gold🇳🇴 · autor de correspondenciaUni Research (Norway)
- for the TIME-A Study Team
Resumen
El texto original del estudio, en el idioma en que se publicó.
Importance
Music therapy may facilitate skills in areas affected by autism spectrum disorder (ASD), such as social interaction and communication.
Objective
To evaluate effects of improvisational music therapy on generalized social communication skills of children with ASD.
Design, setting, and participants
Assessor-blinded, randomized clinical trial, conducted in 9 countries and enrolling children aged 4 to 7 years with ASD. Children were recruited from November 2011 to November 2015, with follow-up between January 2012 and November 2016.
Interventions
Enhanced standard care (n = 182) vs enhanced standard care plus improvisational music therapy (n = 182), allocated in a 1:1 ratio. Enhanced standard care consisted of usual care as locally available plus parent counseling to discuss parents' concerns and provide information about ASD. In improvisational music therapy, trained music therapists sang or played music with each child, attuned and adapted to the child's focus of attention, to help children develop affect sharing and joint attention.
Main outcomes and measures
The primary outcome was symptom severity over 5 months, based on the Autism Diagnostic Observation Schedule (ADOS), social affect domain (range, 0-27; higher scores indicate greater severity; minimal clinically important difference, 1). Prespecified secondary outcomes included parent-rated social responsiveness. All outcomes were also assessed at 2 and 12 months.
Results
Among 364 participants randomized (mean age, 5.4 years; 83% boys), 314 (86%) completed the primary end point and 290 (80%) completed the last end point. Over 5 months, participants assigned to music therapy received a median of 19 music therapy, 3 parent counseling, and 36 other therapy sessions, compared with 3 parent counseling and 45 other therapy sessions for those assigned to enhanced standard care. From baseline to 5 months, mean ADOS social affect scores estimated by linear mixed-effects models decreased from 14.08 to 13.23 in the music therapy group and from 13.49 to 12.58 in the standard care group (mean difference, 0.06 [95% CI, -0.70 to 0.81]; P = .88), with no significant difference in improvement. Of 20 exploratory secondary outcomes, 17 showed no significant difference.
Conclusions and relevance
Among children with autism spectrum disorder, improvisational music therapy, compared with enhanced standard care, resulted in no significant difference in symptom severity based on the ADOS social affect domain over 5 months. These findings do not support the use of improvisational music therapy for symptom reduction in children with autism spectrum disorder.
Trial registration
isrctn.org Identifier: ISRCTN78923965.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.