Modeling the dose effects of soybean oil in salad dressing on carotenoid and fat-soluble vitamin bioavailability in salad vegetables
White WS, Zhou Y, Crane A, Dixon P, Quadt F, Flendrig LM
The American journal of clinical nutrition · 36 citas
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Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
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- Resultado principal
- Marcadores de salud y funcionamiento
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Quién lo pagó
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- Financiación no declarada
Publicación
- Publicado
- 2017-04-01 · Am J Clin Nutr · vol. 106 · número 4 · págs. 1041–1051
- Editorial
- Elsevier BV
- Citado
- 53 citas · más que el 91% de estudios similares · 2.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Antioxidant Activity and Oxidative Stress · Phytochemicals and Antioxidant Activities · Proteins in Food Systems
- Palabras clave
- soybean oil, salad dressing, dose-response relationship, carotenoid absorption, fat-soluble vitamins, vitamin K1, tocopherols, retinyl palmitate, provitamin A carotenoids, chylomicrons, interindividual variability, salad vegetables, lycopene, lutein, alpha-carotene, beta-carotene
- MeSH
- humans, vegetables, carotenoids, vitamin a, lutein, diterpenes, vitamin k 1, soybean oil, chylomicrons, vitamins, tocopherols, diet, area under curve, biological availability, intestinal absorption, dose-response relationship, drug, solubility, models, biological, adult, female, young adult, lycopene, retinyl esters
6 autores
- Wendy S. White🇺🇸 · autor de correspondenciaIowa State University
- Yang Zhou🇺🇸Iowa State University
- Agatha Crane🇺🇸Iowa State University
- Philip M. Dixon🇺🇸Iowa State University
- Frits Quadt
- Leonard M. Flendrig🇳🇱Unilever Research and Development Vlaardingen
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: Previously, we showed that vegetable oil is necessary for carotenoid absorption from salad vegetables. Research is needed to better define the dose effect and its interindividual variation for carotenoids and fat-soluble vitamins.Objective: The objective was to model the dose-response relation between the amount of soybean oil in salad dressing and the absorption of 1) carotenoids, phylloquinone, and tocopherols in salad vegetables and 2) retinyl palmitate formed from the provitamin A carotenoids.Design: Women (n = 12) each consumed 5 vegetable salads with salad dressings containing 0, 2, 4, 8, or 32 g soybean oil. Blood was collected at selected time points. The outcome variables were the chylomicron carotenoid and fat-soluble vitamin area under the curve (AUC) and maximum content in the plasma chylomicron fraction (Cmax). The individual-specific and group-average dose-response relations were investigated by fitting linear mixed-effects random coefficient models.Results: Across the entire 0-32-g range, soybean oil was linearly related to the chylomicron AUC and Cmax values for α-carotene, lycopene, phylloquinone, and retinyl palmitate. Across 0-8 g of soybean oil, there was a linear increase in the chylomicron AUC and Cmax values for β-carotene. Across a more limited 0-4-g range of soybean oil, there were minor linear increases in the chylomicron AUC for lutein and α- and total tocopherol. Absorption of all carotenoids and fat-soluble vitamins was highest with 32 g oil (P P Conclusions: Within the linear range, the average absorption of carotenoids and fat-soluble vitamins could be largely predicted by the soybean oil effect. However, the effect varied widely, and some individuals showed a negligible response. There was a global soybean oil effect such that those who absorbed more of one carotenoid and fat-soluble vitamin also tended to absorb more of the others. This trial was registered at clinicaltrials.gov as NCT02867488.
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