Caffeine as an opioid analgesic adjuvant in fibromyalgia
Scott JR, Hassett AL, Brummett CM, Harris RE, Clauw DJ, Harte SE
Journal of pain research · 12 citas
Etiquetas de revisión
Vínculos de autores con la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio transversal (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Posiblemente financiado por la industria
- Organización sin fines de lucro
- American Pain Society
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-07-01 · J Pain Res · vol. Volume 10 · págs. 1801–1809
- Editorial
- Dove Medical Press
- Citado
- 28 citas · más que el 83% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 63 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Coffee research and impacts · Fibromyalgia and Chronic Fatigue Syndrome Research · Forensic Toxicology and Drug Analysis
- Palabras clave
- Caffeine, Medicine, Fibromyalgia, Opioid, Analgesic, Acetaminophen, Anesthesia, Chronic pain, Internal medicine, Physical therapy
6 autores
- J. Ryan Scott🇺🇸Pain and Headache Center
- Afton L. Hassett🇺🇸Pain and Headache Center
- Chad M. Brummett🇺🇸Pain and Headache Center
- Richard Edmund Harris🇺🇸University of Michigan; Pain and Headache Center
- Daniel Joseph Clauw🇺🇸University of Michigan; Pain and Headache Center
- Steven E. Harte🇺🇸University of Michigan; Pain and Headache Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Caffeine's properties as an analgesic adjuvant with nonsteroidal anti-inflammatory drugs/acetaminophen are well documented. However, little clinical research has explored caffeine's effects on opioid analgesia. This study assessed the effects of caffeine consumption on pain and other symptoms in opioid-using and nonusing chronic pain patients meeting the survey criteria for fibromyalgia.
Materials and methods
Patients presenting to a university-based pain clinic completed validated self-report questionnaires assessing symptoms. Patients (N=962) meeting the fibromyalgia survey criteria were stratified by opioid use and further split into groups based on caffeine amount consumed per day (no caffeine, or low, moderate, high caffeine). Analysis of covariance with Dunnett's post hoc testing compared pain and symptom severity between the no caffeine group and the caffeine consuming groups.
Results
In opioid users, caffeine consumption had modest but significant effects on pain, catastrophizing, and physical function. Lower levels of pain interference were associated with low and moderate caffeine use compared to no caffeine intake. Lower pain catastrophizing and higher physical function were observed in all caffeine dose groups, relative to the no caffeine group. Lower pain severity and depression were observed only in the moderate caffeine group. In opioid nonusers, low caffeine intake was associated with higher physical function; however, no other significant effects were observed.
Conclusion
Caffeine consumption was associated with decreased pain and symptom severity in opioid users, but not in opioid nonusers, indicating caffeine may act as an opioid adjuvant in fibromyalgia-like chronic pain patients. These data suggest that caffeine consumption concomitant with opioid analgesics could provide therapeutic benefits not seen with opioids or caffeine alone.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.