Drinking water to reduce alcohol craving? A randomized controlled study on the impact of ghrelin in mediating the effects of forced water intake in alcohol addiction
Koopmann A, Lippmann K, Schuster R, Reinhard I, Bach P, Weil G, Rietschel M, Witt SH, Wiedemann K, Kiefer F
Psychoneuroendocrinology · 14 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Bundesministerium für Bildung und Forschung
- Sin clasificar
- SysMedAlcoholism
- Gobierno
- BMBF
Según 3 financiadores declarados.
Publicación
- Publicado
- 2017-08-05 · Psychoneuroendocrinology · vol. 85 · págs. 56–62
- Editorial
- Elsevier BV
- Citado
- 17 citas · más que el 78% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 47 trabajos
- Acceso
- De pago
- Áreas de investigación
- Regulation of Appetite and Obesity · Substance Abuse Treatment and Outcomes · Alcohol Consumption and Health Effects
- Palabras clave
- alcohol craving, ghrelin, alcoholism, alcohol cue exposure, gastric distension, plasma ghrelin, ghrelin antagonist, craving reduction
- MeSH
- humans, alcoholism, substance withdrawal syndrome, adult, middle aged, male, ghrelin, drinking water, craving, outcome assessment, health care
10 autores
- Anne Koopmann🇩🇪 · autor de correspondenciaHeidelberg University; Central Institute of Mental Health; Medizinische Fakultät Mannheim
- Katharina Isabel Lippmann🇩🇪Heidelberg University; Central Institute of Mental Health; Medizinische Fakultät Mannheim
- Rilana Schuster🇩🇪Heidelberg University; Central Institute of Mental Health; Medizinische Fakultät Mannheim
- Iris Reinhard🇩🇪Heidelberg University; Central Institute of Mental Health; Medizinische Fakultät Mannheim
- Patrick Bach🇩🇪Heidelberg University; Central Institute of Mental Health; Medizinische Fakultät Mannheim
- Georg Weil🇩🇪Heidelberg University; Central Institute of Mental Health; Medizinische Fakultät Mannheim
- Marcella Rietschel🇩🇪Heidelberg University; Central Institute of Mental Health; Medizinische Fakultät Mannheim
- Stephanie H. Witt🇩🇪Heidelberg University; Central Institute of Mental Health; Medizinische Fakultät Mannheim
- Klaus Wiedemann🇩🇪Universität Hamburg; University Medical Center Hamburg-Eppendorf
- Falk Kiefer🇩🇪Heidelberg University; Central Institute of Mental Health; Medizinische Fakultät Mannheim
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Recent data suggest that ghrelin is involved in the pathophysiology of alcohol use disorders, affecting alcohol self-administration and craving. Gastric ghrelin secretion is reduced by stomach distension. We now tested the hypothesis whether the clinically well-known effects of high-volume water intake on craving reduction in alcoholism is mediated by acute changes in ghrelin secretion.
Methods
In this randomized human laboratory study, we included 23 alcohol-dependent male inpatient subjects who underwent alcohol cue exposure. Participants of the intervention group drank 1000ml of mineral water within 10min directly thereafter, compared to the participants of the control group who did not. Craving and plasma concentrations of acetylated ghrelin were measured ten times during the 120min following the alcohol cue exposure session.
Results
In the intervention group, a significant decrease in acetylated ghrelin in plasma compared to the control group was observed. This decrease was correlated to a reduction in patients' subjective level of craving. In the control group, no decrease of acetylated ghrelin in plasma and no association between alcohol craving and changes in plasma concentrations of acetylated ghrelin were observed.
Conclusions
Our results present new evidence that the modulation in the ghrelin system by oral water intake mediates the effects of volume intake with craving reduction in alcohol use disorders. Hence, in addition to pharmacological interventions with ghrelin antagonists, the reduction of physiological ghrelin secretion might be a target for future interventions in the treatment of alcohol craving.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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