Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial
Sharma AK, Basu I, Singh S
Journal of alternative and complementary medicine (New York, N.Y.) · 66 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2017-08-22 · J Altern Complement Med · vol. 24 · número 3 · págs. 243–248
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 115 citas · más que el 92% de estudios similares · 2.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 18 trabajos
- Acceso
- De pago
- Áreas de investigación
- Thyroid Disorders and Treatments · Phytochemicals and Medicinal Plants
- Palabras clave
- Medicine, Subclinical infection, Placebo, Withania somnifera, Internal medicine, Triiodothyronine, Thyroid, Population, Randomized controlled trial, Alternative medicine
- MeSH
- humans, withania, hypothyroidism, thyroid hormones, plant extracts, prospective studies, pilot projects, double-blind method, adult, female, male
3 autores
- Ashok Kumar Sharma
- Indraneel Basu
- Siddarth Singh
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Subclinical hypothyroidism, a thyroid disorder without obvious symptoms of thyroid deficiency, occurs in 3%-8% of the global population. Ashwagandha [Withania somnifera (L.) Dunal], a traditional medicine in Ayurveda, is often prescribed for thyroid dysfunctions.
Objective
This pilot study was designed to evaluate the efficacy and safety of ashwagandha root extract in subclinical hypothyroid patients.
Design, setting, and participants
A prospective, randomized, double-blind, single-center placebo-controlled study was performed at Sudbhawana Hospital, Varanasi, India between May 2016 and September 2016. Fifty subjects with elevated serum thyroid stimulating hormone (TSH) levels (4.5-10 μIU/L) aged between 18 and 50 were randomized in either treatment (n = 25) or placebo (n = 25) groups for an 8-week treatment period.
Interventions
Ashwagandha root extract (600 mg daily) or starch as placebo. Efficacy Variables: Serum TSH, serum triiodothyronine (T3), and thyroxine (T4) levels.
Results
A total of four subjects (two from each group) withdrew their consent before the second visit. Eight weeks of treatment with ashwagandha improved serum TSH (p < 0.001), T3 (p = 0.0031), and T4 (p = 0.0096) levels significantly compared to placebo. Ashwagandha treatment effectively normalized the serum thyroid indices during the 8-week treatment period in a significant manner (time-effects: TSH [p < 0.001], T3 [p < 0.001], and T4 [p < 0.001]). Four subjects (8%) (ashwagandha: 1[4%]; Placebo: 3[12%]) out of 50 reported few mild and temporary adverse effects during this study.
Conclusion
Treatment with ashwagandha may be beneficial for normalizing thyroid indices in subclinical hypothyroid patients.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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