Supplementing Breakfast with a Vitamin D and Leucine-Enriched Whey Protein Medical Nutrition Drink Enhances Postprandial Muscle Protein Synthesis and Muscle Mass in Healthy Older Men
Chanet A, Verlaan S, Salles J, Giraudet C, Patrac V, Pidou V, Pouyet C, Hafnaoui N, Blot A, Cano N, Farigon N, Bongers A, Jourdan M, Luiking Y, Walrand S, Boirie Y
The Journal of nutrition · 94 citas
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Publicación
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- 2017-08-24 · J Nutr · vol. 147 · número 12 · págs. 2262–2271
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- Elsevier BV
- Citado
- 143 citas · más que el 98% de estudios similares · 6.7× el promedio de su campo
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- Entre el 10 % más citado de su campo
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- 58 trabajos
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- Áreas de investigación
- Muscle metabolism and nutrition · Nutrition and Health in Aging · Muscle Physiology and Disorders
- Palabras clave
- whey protein, leucine, vitamin D, vitamin D3, muscle protein synthesis, appendicular lean mass, muscle mass, sarcopenia, older men, muscle anabolism, high-quality protein, leg lean mass, phenylalanine tracer, protein intake, healthy aging
- MeSH
- muscle, skeletal, humans, vitamin d, leucine, muscle proteins, diet, double-blind method, food analysis, gene expression regulation, energy intake, postprandial period, beverages, aged, male, breakfast, whey proteins
16 autores
- Audrey Chanet🇫🇷Université Clermont Auvergne; Unité de Nutrition Humaine; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Centre de Recherche en Nutrition Humaine d'Auvergne
- Sjors Verlaan🇳🇱Nutricia Research (Netherlands); Vrije Universiteit Amsterdam; Amsterdam UMC Location Vrije Universiteit Amsterdam
- Jérôme Salles🇫🇷Université Clermont Auvergne; Unité de Nutrition Humaine; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Centre de Recherche en Nutrition Humaine d'Auvergne
- Christophe Giraudet🇫🇷Université Clermont Auvergne; Unité de Nutrition Humaine; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Centre de Recherche en Nutrition Humaine d'Auvergne
- Véronique Patrac🇫🇷Université Clermont Auvergne; Unité de Nutrition Humaine; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Centre de Recherche en Nutrition Humaine d'Auvergne
- Véronique Pidou🇫🇷Centre de Recherche en Nutrition Humaine d'Auvergne
- Corinne Pouyet🇫🇷Université Clermont Auvergne; Unité de Nutrition Humaine; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
- Nordine Hafnaoui🇫🇷Université Clermont Auvergne; Unité de Nutrition Humaine; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Centre de Recherche en Nutrition Humaine d'Auvergne
- Adeline Blot🇫🇷Centre de Recherche en Nutrition Humaine d'Auvergne
- Noël Cano🇫🇷Centre Hospitalier Universitaire de Clermont-Ferrand; Centre de Recherche en Nutrition Humaine d'Auvergne
- Nicolas Farigon🇫🇷Centre Hospitalier Universitaire de Clermont-Ferrand
- Anke Bongers🇳🇱Nutricia Research (Netherlands)
- Marion Jourdan🇳🇱Nutricia Research (Netherlands)
- Yvette C. Luiking🇳🇱Nutricia Research (Netherlands)
- Stéphane Walrand🇫🇷Université Clermont Auvergne; Unité de Nutrition Humaine; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Centre de Recherche en Nutrition Humaine d'Auvergne
- Yves Boirie🇫🇷 · autor de correspondenciaUniversité Clermont Auvergne; Unité de Nutrition Humaine; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Centre Hospitalier Universitaire de Clermont-Ferrand; Centre de Recherche en Nutrition Humaine d'Auvergne
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: A promising strategy to help older adults preserve or build muscle mass is to optimize muscle anabolism through providing an adequate amount of high-quality protein at each meal.Objective: This "proof of principle" study investigated the acute effect of supplementing breakfast with a vitamin D and leucine-enriched whey protein medical nutrition drink on postprandial muscle protein synthesis and longer-term effect on muscle mass in healthy older adults.Methods: A randomized, placebo-controlled, double-blind study was conducted in 24 healthy older men [mean ± SD: age 71 ± 4 y; body mass index (in kg/m2) 24.7 ± 2.8] between September 2012 and October 2013 at the Unit of Human Nutrition, University of Auvergne, Clermont-Ferrand, France. Participants received a medical nutrition drink [test group; 21 g leucine-enriched whey protein, 9 g carbohydrates, 3 g fat, 800 IU cholecalciferol (vitamin D3), and 628 kJ] or a noncaloric placebo (control group) before breakfast for 6 wk. Mixed muscle protein fractional synthesis rate (FSR) was measured at week 0 in the basal and postprandial state, after study product intake with a standardized breakfast with the use of l-[2H5]-phenylalanine tracer methodology. The longer-term effect of the medical nutrition drink was evaluated by measurement of appendicular lean mass, representing skeletal muscle mass at weeks 0 and 6, by dual-energy X-ray absorptiometry.Results: Postprandial FSR (0-240 min) was higher in the test group than in the control group [estimate of difference (ED): 0.022%/h; 95% CI: 0.010%/h, 0.035%/h; ANCOVA, P = 0.001]. The test group gained more appendicular lean mass than the control group after 6 wk (ED: 0.37 kg; 95% CI: 0.03, 0.72 kg; ANCOVA, P = 0.035), predominantly as leg lean mass (ED: 0.30 kg; 95% CI: 0.03, 0.57 kg; ANCOVA, P = 0.034).Conclusions: Supplementing breakfast with a vitamin D and leucine-enriched whey protein medical nutrition drink stimulated postprandial muscle protein synthesis and increased muscle mass after 6 wk of intervention in healthy older adults and may therefore be a way to support muscle preservation in older people. This trial was registered at www.trialregister.nl as NTR3471.
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