A Model of Exposure to Extreme Environmental Heat Uncovers the Human Transcriptome to Heat Stress
Bouchama A, Aziz MA, Mahri SA, Gabere MN, Dlamy MA, Mohammad S, Abbad MA, Hussein M
Scientific reports · 59 citas
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Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- King Abdullah International Medical Research Center
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-08-21 · Sci Rep · vol. 7 · número 1 · pág. 9429
- Editorial
- Nature Portfolio
- Citado
- 89 citas · más que el 76% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 75 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Climate Change and Health Impacts · Thermoregulation and physiological responses · Adipose Tissue and Metabolism
- Palabras clave
- Transcriptome, Proteostasis, Heat shock protein, Biology, Heat stress, Heat shock, Gene, Extreme heat, Gene expression, Function (biology), Cell biology, Genetics, Ecology
- MeSH
- humans, reproducibility of results, gene expression profiling, environmental exposure, signal transduction, heat-shock response, adult, female, male, young adult, extreme heat, transcriptome, biomarkers
8 autores
- Abderrezak Bouchama🇸🇦 · autor de correspondenciaKing Saud bin Abdulaziz University for Health Sciences; King Abdullah International Medical Research Center
- Mohammad Azhar Aziz🇸🇦King Saud bin Abdulaziz University for Health Sciences; King Abdullah International Medical Research Center
- Saeed Al Mahri🇸🇦King Saud bin Abdulaziz University for Health Sciences; King Abdullah International Medical Research Center
- Musa Nur Gabere🇸🇦King Saud bin Abdulaziz University for Health Sciences; King Abdullah International Medical Research Center
- Meshan Al Dlamy🇸🇦King Saud bin Abdulaziz University for Health Sciences; King Abdullah International Medical Research Center
- Sameer Mohammad🇸🇦King Saud bin Abdulaziz University for Health Sciences; King Abdullah International Medical Research Center
- Mashael Al Abbad🇸🇦King Saud bin Abdulaziz University for Health Sciences; King Abdullah International Medical Research Center
- Mohamed Hussein🇸🇦King Saud bin Abdulaziz University for Health Sciences; King Abdullah International Medical Research Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
The molecular mechanisms by which individuals subjected to environmental heat stress either recover or develop heat-related complications are not well understood. We analysed the changes in blood mononuclear gene expression patterns in human volunteers exposed to extreme heat in a sauna (temperature of 75.7 ± 0.86 °C). Our analysis reveals that expression changes occur rapidly with no significant increase in core temperature and continue to amplify one hour after the end of heat stress. The reprogramed transcriptome was predominantly inhibitory, as more than two-thirds of the expressed genes were suppressed. The differentially expressed genes encoded proteins that function in stress-associated pathways; including proteostasis, energy metabolism, cell growth and proliferation, and cell death, and survival. The transcriptome also included mitochondrial dysfunction, altered protein synthesis, and reduced expression of genes -related to immune function. The findings reveal the human transcriptomic response to heat and highlight changes that might underlie the health outcomes observed during heat waves.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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