Financiado en parte por Astellas Pharma
Effect of Magnesium Supplements on Insulin Secretion After Kidney Transplantation: A Randomized Controlled Trial
Van Laecke S, Caluwe R, Huybrechts I, Nagler EV, Vanholder R, Peeters P, Van Vlem B, Van Biesen W
Annals of transplantation · 19 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- World Health Organization
- Empresa
- Astellas Pharma
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-08-29 · Ann Transplant · vol. 22 · págs. 524–531
- Editorial
- International Scientific Information Inc.
- Citado
- 21 citas · más que el 85% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 28 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Potassium and Related Disorders
- Palabras clave
- Hypomagnesemia, Medicine, Internal medicine, Endocrinology, Transplantation, Insulin, Insulin resistance, Glycemic, Diabetes mellitus, Magnesium deficiency (plants), Kidney transplantation, Magnesium, Chemistry
- MeSH
- humans, magnesium, tacrolimus, insulin, blood glucose, immunosuppressive agents, treatment outcome, kidney transplantation, graft rejection, dietary supplements, adult, aged, middle aged, female, male, insulin secretion, glycated hemoglobin
8 autores
- Steven Van Laecke🇧🇪 · autor de correspondenciaGhent University Hospital
- Rogier Caluwé🇧🇪Onze Lieve Vrouwziekenhuis Hospital
- Inge Huybrechts🇧🇪Ghent University
- Evi Vanessa Nagler🇧🇪Ghent University Hospital
- Raymond Camille Vanholder🇧🇪Ghent University Hospital
- Patrick C. Peeters🇧🇪Ghent University Hospital
- Bruno Van Vlem🇧🇪Onze Lieve Vrouwziekenhuis Hospital
- Wim Van Biesen🇧🇪Ghent University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
BACKGROUND Hypomagnesemia is associated with a disturbed glucose metabolism. Insulin hypo-secretion predicts diabetes in the general population and in transplant recipients. We aimed to assess whether magnesium improves insulin secretion and glycemic control after transplantation in prevalent hypomagnesemic kidney transplant recipients. MATERIAL AND METHODS We conducted an open-label, randomized, parallel-group study. Eligible participants were adults more than 4 months after kidney transplantation on tacrolimus with persisting serum magnesium concentrations <1.8 mg/dL randomized to magnesium oxide supplementation up to a maximum of 3 times 450 mg daily (N=26) or no supplements (N=26). Insulin secretion was assessed by OGTT-derived, first-phase insulin secretion (FPIR). The primary endpoint was the mean difference in FPIR between baseline and 6 months after randomization. Secondary endpoints were differences in HbA1c and insulin resistance, measured by HOMA. Dietary magnesium was assessed by a food-frequency questionnaire. All analyses were done on an intention-to-treat basis. RESULTS Magnesium with a mean daily dose of 688±237mg in the treatment group failed to lead to significant differences between the 2 groups in FPIR, fasting glucose, HbA1c, or HOMA-IR. Persisting hypomagnesemia was very common and associated with more insulin hypo-secretion, glucose intolerance, and lower dietary magnesium intake (142±56 versus 202±90 mg; p=0.015) as compared to patients with a rise in serum magnesium over 6 months. CONCLUSIONS Magnesium supplementation does not improve insulin secretion in stable hypomagnesemic kidney transplant recipients on tacrolimus. Persisting hypomagnesemia is associated with impaired glucose tolerance, insulin hypo-secretion, and dietary factors.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.