Strain-specific probiotic (microbial cell preparation) and omega-3 fatty acid in modulating quality of life and inflammatory markers in colorectal cancer patients: a randomized controlled trial
Golkhalkhali B, Rajandram R, Paliany AS, Ho GF, Wan Ishak WZ, Johari CS, Chin KF
Asia-Pacific journal of clinical oncology · 80 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Universiti Malaya
- Universidad u hospital
- University of Malaya's High Impact Research (HIR)
- Subvenciones
- Universiti Malaya (UM.C/HIR/MOHE/06/H-5001-00-A000020-000001)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2017-08-31 · Asia Pac J Clin Oncol · vol. 14 · número 3 · págs. 179–191
- Editorial
- Wiley
- Citado
- 97 citas · más que el 96% de estudios similares · 5.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 30 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Probiotics and Fermented Foods · Cancer survivorship and care · Complementary and Alternative Medicine Studies
- Palabras clave
- colorectal cancer, chemotherapy side effects, probiotics, omega-3 fatty acids, quality of life, inflammatory markers, interleukin-6, TNF-α, C-reactive protein, dietary supplementation
- MeSH
- humans, colorectal neoplasms, fatty acids, omega-3, double-blind method, quality of life, probiotics, aged, middle aged, female, male
7 autores
- Babak Golkhalkhali🇲🇾University of Malaya
- Retnagowri Rajandram🇲🇾 · autor de correspondenciaUniversity of Malaya
- Audra Shaleena Paliany🇲🇾University of Malaya
- Gwo Fuang Ho🇲🇾University of Malaya
- Wan Zamaniah Wan Ishak🇲🇾University of Malaya
- Che Shafini Johari🇲🇾University Malaya Medical Centre
- Kin Fah Chin🇲🇾Universiti Tunku Abdul Rahman Sungai Long Campus; Universiti Tunku Abdul Rahman
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aim
Colorectal cancer patients on chemotherapy usually have elevated levels of inflammatory markers and experience numerous side effects from chemotherapy thereby leading to poor quality of life. Omega-3 fatty acid and microbial cell preparation (MCP) have been known to provide significant benefits in patients on chemotherapy. The aim of this study was to determine the effect of supplementation of omega-3 fatty acid and MCP in quality of life, chemotherapy side effects and inflammatory markers in colorectal cancer patients on chemotherapy.
Methods
A double-blind randomized study was carried out with 140 colorectal cancer patients on chemotherapy. Subjects were separated into two groups to receive either placebo or MCP [30 billion colony-forming unit (CFUs) per sachet] at a dose of two sachets daily for 4 weeks, and omega-3 fatty acid at a dose of 2 g daily for 8 weeks. Outcomes measured were quality of life, side effects of chemotherapy and levels of inflammatory markers such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein.
Results
The supplementation with MCP and omega-3 fatty acid improved the overall quality of life and alleviated certain side effects of chemotherapy. The supplementation with MCP and omega-3 fatty acid also managed to reduce the level of IL-6 (P = 0.002). There was a significant rise in the placebo group's serum TNF-α (P = 0.048) and IL-6 (P = 0.004).
Conclusion
The combined supplementation with MCP and omega-3 fatty acid may improve quality of life, reduce certain inflammatory biomarkers and relieve certain side effects of chemotherapy in colorectal patients on chemotherapy.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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