Effect of 1-y oral supplementation with vitaminized olive oil on platelets from healthy postmenopausal women
Vignini A, Nanetti L, Raffaelli F, Sabbatinelli J, Salvolini E, Quagliarini V, Cester N, Mazzanti L
Nutrition (Burbank, Los Angeles County, Calif.) · 10 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
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Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2017-07-05 · Nutrition · vol. 42 · págs. 92–98
- Editorial
- Elsevier BV
- Citado
- 11 citas · más que el 49% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 61 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY-NC-ND
- Áreas de investigación
- Edible Oils Quality and Analysis · Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress
- Palabras clave
- extra virgin olive oil, vitamin D3, vitamin K1, vitamin B6, postmenopausal women, platelets, platelet membrane fluidity, nitrosative stress, nitric oxide, peroxynitrite, Na+/K+-ATPase, osteoporosis, bone health, antioxidant activity, Mediterranean diet
- MeSH
- blood platelets, humans, nitric oxide, peroxynitrous acid, vitamin k 1, cholecalciferol, vitamins, vitamin b 6, oxidative stress, postmenopause, dietary supplements, middle aged, female, olive oil, nitrosative stress
8 autores
- Arianna Vignini🇮🇹Marche Polytechnic University
- Laura Nanetti🇮🇹Marche Polytechnic University
- Francesca Raffaelli🇮🇹Marche Polytechnic University
- Jacopo Sabbatinelli🇮🇹 · autor de correspondenciaMarche Polytechnic University
- Eleonora Salvolini🇮🇹Marche Polytechnic University
- Veronica Quagliarini
- Nelvio Cester
- Laura Mazzanti🇮🇹Marche Polytechnic University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Olive oil is the main fat source in the Mediterranean diet and shows a protective role against aging and related diseases. Osteoporosis represents a serious health problem worldwide and is associated with an increased risk for fractures and mortality. Nutrition should be part of bone disease prevention strategies, especially in light of the aging population and the effect of diet on bone health. The aim of this study was to investigate whether oral supplementation with extra virgin olive oil (VOO) enriched with vitamins D3, K1, and B6 (VitVOO) is able to modify some physicochemical and functional plasma membrane properties and nitrosative stress markers status.
Methods
In this single-center, randomized placebo-controlled trial, 60 postmenopausal women were administered either VitVOO or placebo (PlaVOO). After 1 y of oral supplementation, platelet membrane fluidity changes, Na+/K+-ATPase activity, serum nitric oxide, and peroxynitrite levels were determined in participants.
Results
After 1 y (time 1), women taking VitVOO showed lower nitric oxide levels than those taking PlaVOO; the same trend was found for peroxynitrite levels. As far as membrane fluidity was concerned, a significant decrease in anisotropy of diphenylhexatriene and trimethylammonium-diphenylhexatriene at time 1 in VitVOO participants compared with PlaVOO was found. Finally, Na+/K+-ATPase activity showed a significant increase after VitVOO supplementation.
Conclusion
The supplementation of VitVOO into the diet of postmenopausal women could represent a proper tool for platelet function and a useful strategy against nitrosative stress and related diseases, thus confirming the antioxidant role played by the added vitamins.
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