In vitro Biological Effects of Sulforaphane (SFN), Epigallocatechin-3-gallate (EGCG), and Curcumin on Breast Cancer Cells: A Systematic Review of the Literature
Gianfredi V, Nucci D, Vannini S, Villarini M, Moretti M
Nutrition and cancer · 30 citas
Etiquetas de revisión
Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Células o muestras de laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2017-09-05 · Nutr Cancer · vol. 69 · número 7 · págs. 969–978
- Editorial
- Routledge
- Citado
- 38 citas · más que el 33% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 56 trabajos
- Acceso
- De pago
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Curcumin's Biomedical Applications · Phytochemicals and Antioxidant Activities
- Palabras clave
- sulforaphane, epigallocatechin gallate, curcumin, breast cancer, epigenetics, DNA methylation, histone acetylation, microRNA, apoptosis, cell cycle regulation, anticancer mechanism, tumor markers
- MeSH
- cell line, tumor, humans, breast neoplasms, curcumin, isothiocyanates, sulfoxides, catechin, telomerase, antineoplastic agents, phytogenic, cell cycle, apoptosis, epigenesis, genetic, female
5 autores
- Vincenza Gianfredi🇮🇹 · autor de correspondenciaUniversity of Perugia
- Daniele Nucci🇮🇹Istituto Oncologico Veneto
- Samuele Vannini🇮🇹University of Perugia
- Milena Villarini🇮🇹University of Perugia
- Massimo Moretti🇮🇹University of Perugia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Much of the recent research in neoplasia has been focusing on the epigenetics of cancer cells, particularly as regards the search for potential molecular biomarkers that could be used for early diagnosis, effective treatment, and prognosis of several types of cancer. Carcinogenesis often starts with mutations in oncogenes and tumor suppressor genes, and it leads to anomalies in cellular processes as vital as cell cycle regulation and apoptosis. Because malignant changes arise as a result of genetic as well as epigenetic mechanisms, one possible means of intervention involves reprogramming gene expression, so as to-at least in part-revert the molecular alterations. DNA methylation and demethylation, acetylation and deacetylation of histones, and microRNAs are a few examples of the epigenetic mechanisms responsible for tumor development and progression. Many biologically active compounds present in food-including sulforaphane, curcumin, and epigallocatechin-have been found to modulate those processes. We here systematically review information on the effects of such bioactive dietary compounds on human breast cancer cell lines, and explore the mechanisms underlying those effects with a view to their potential therapeutic application.
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