Do nitric oxide synthase and cyclooxygenase contribute to sweating response during passive heating in endurance-trained athletes?
Amano T, Fujii N, Kenny GP, Inoue Y, Kondo N
Physiological reports · 7 citas
Cómo se estudió
- Diseño
- Estudio de casos y controles (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministry of Education, Culture, Sports, Science and Technology
- Gobierno
- Japan Society for the Promotion of Science
- Subvenciones
- Japan Society for the Promotion of Science (16K16521)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-09-01 · Physiol Rep · vol. 5 · número 17 · pág. e13403
- Editorial
- Wiley
- Citado
- 9 citas · más que el 70% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 38 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Thermoregulation and physiological responses · Infrared Thermography in Medicine · Exercise and Physiological Responses
- Palabras clave
- SWEAT, Microdialysis, Ketorolac, Nitric oxide synthase, Cyclooxygenase, Nitric oxide, Thermoregulation, Medicine, Heart rate, Internal medicine, Endocrinology, Anesthesia, Chemistry, Biochemistry, Enzyme, Blood pressure, Analgesic
- MeSH
- sweat glands, humans, ketorolac, ng-nitroarginine methyl ester, cyclooxygenase inhibitors, exercise, case-control studies, acclimatization, sweating, physical endurance, female, male, prostaglandin-endoperoxide synthases, nitric oxide synthase, hot temperature, young adult
5 autores
- Tatsuro Amano🇯🇵 · autor de correspondenciaNiigata University
- Naoto Fujii🇯🇵University of Tsukuba; Tsukuba University of Technology
- Glen Patrick Kenny🇨🇦University of Ottawa
- Yoshimitsu Inoue🇯🇵Osaka International University
- Narihiko Kondo🇯🇵Kobe University
Resumen
El texto original del estudio, en el idioma en que se publicó.
The aim of our study was to determine if habitual endurance training can influence the relative contribution of nitric oxide synthase (NOS) and cyclooxygenase (COX) in the regulation of sweating during a passive heat stress in young adults. Ten trained athletes and nine untrained counterparts were passively heated until oral temperature (as estimated by sublingual temperature, Tor) increased by 1.5°C above baseline resting. Forearm sweat rate (ventilated capsule) was measured at three skin sites continuously perfused with either lactated Ringer's solution (Control), 10 mmol/L NG -nitro-L-arginine methyl ester (L-NAME, non-selective NOS inhibitor), or 10 mmol/L ketorolac (Ketorolac, non-selective COX inhibitor) via intradermal microdialysis. Sweat rate was averaged for each 0.3°C increase in Tor Sweat rate at the L-NAME site was lower than Control following a 0.9 and 1.2°C increase in Tor in both groups (all P ≤ 0.05). Relative to the Control site, NOS-inhibition reduced sweating similarly between the groups (P = 0.51). Sweat rate at the Ketorolac site was not different from the Control at any levels of Tor in both groups (P > 0.05). Nevertheless, a greater sweat rate was measured at the end of heating in the trained as compared to the untrained individuals (P ≤ 0.05). We show that NOS contributes similarly to sweating in both trained and untrained individuals during a passive heat stress. Further, no effect of COX on sweating was measured for either group. The greater sweat production observed in endurance-trained athletes is likely mediated by factors other than NOS- and COX-dependent mechanisms.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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