Financiado en parte por Bayer HealthCare
25-Hydroxyvitamin D deficiency and risk of MS among women in the Finnish Maternity Cohort
Munger KL, Hongell K, Åivo J, Soilu-Hänninen M, Surcel HM, Ascherio A
Neurology · 44 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Bayer HealthCare
- Gobierno
- Kela
- Gobierno
- Terveyden ja hyvinvoinnin laitos
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute of Neurological Disorders and Stroke
- Gobierno
- NINDS NIH HHS
- Subvenciones
- National Institute of Neurological Disorders and Stroke (R01 NS073633)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2017-09-14 · Neurology · vol. 89 · número 15 · págs. 1578–1583
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 65 citas · más que el 98% de estudios similares · 6.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 14 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Multiple Sclerosis Research Studies · Vitamin D Research Studies · Pregnancy and Medication Impact
- Palabras clave
- Medicine, Vitamin D and neurology, Confidence interval, Relative risk, vitamin D deficiency, Prospective cohort study, Cohort, Cohort study, Odds ratio, Logistic regression, Obstetrics, Internal medicine, Gynecology
- MeSH
- humans, multiple sclerosis, vitamin d deficiency, vitamin d, severity of illness index, case-control studies, cohort studies, age factors, pregnancy, adult, middle aged, finland, female, young adult
6 autores
- Kassandra L. Munger🇫🇮Finnish Institute for Health and Welfare
- Kira Hongell🇫🇮Finnish Institute for Health and Welfare
- Julia Åivo🇫🇮Finnish Institute for Health and Welfare
- Merja Soilu‐Hänninen🇫🇮Finnish Institute for Health and Welfare
- Heljä‐Marja Surcel🇫🇮Finnish Institute for Health and Welfare
- Alberto Ascherio🇫🇮Finnish Institute for Health and Welfare
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To determine whether and to what extent vitamin D deficiency is associated with multiple sclerosis (MS) risk.
Methods
We conducted a prospective nested case-control study among women in the Finnish Maternity Cohort (FMC). The FMC had 1.8 million stored serum samples taken during the pregnancies of over 800,000 women at the time of this study. Through linkages with hospital and prescription registries, we identified 1,092 women with MS diagnosed between 1983 and 2009 with at least 1 serum sample collected prior to date of MS diagnosis; ≥2 serum samples were available for 511 cases. Cases were matched to up to 3 controls (n = 2,123) on date of birth (±2 years) and area of residence. 25-Hydroxyvitamin D (25[OH]D) levels were measured using a chemiluminescence assay. We used conditional logistic regression adjusted for year of sample collection, gravidity, and parity to estimate relative risks (RRs) and 95% confidence intervals (CIs).
Results
A 50 nmol/L increase in 25(OH)D was associated with a 39% reduced risk of MS (RR 0.61, 95% CI 0.44-0.85), p = 0.003. Women with 25(OH)D levels p = 0.04) as compared to women with levels ≥50 nmol/L. In women with ≥2 samples, MS risk was 2-fold higher in women with 25(OH)D p = 0.01).
Conclusions
These results directly support vitamin D deficiency as a risk factor for MS and strengthen the rationale for broad public health interventions to improve vitamin D levels.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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