Dietary Nitrate Increases VO2peak and Performance but Does Not Alter Ventilation or Efficiency in Patients With Heart Failure With Reduced Ejection Fraction
Coggan AR, Broadstreet SR, Mahmood K, Mikhalkova D, Madigan M, Bole I, Park S, Leibowitz JL, Kadkhodayan A, Thomas DP, Thies D, Peterson LR
Journal of cardiac failure · 46 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Foundation for Barnes-Jewish Hospital
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NCATS NIH HHS
- Universidad u hospital
- Washington University Institute of Clinical and Translational Sciences
- Organización sin fines de lucro
- Barnes-Jewish Hospital Foundation
- Gobierno
- NIDDK NIH HHS
- Universidad u hospital
- Washington University Mentors in Medicine and C-STAR programs
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK056341); National Center for Advancing Translational Sciences (UL1-TR-000448); National Center for Advancing Translational Sciences (UL1TR002345)
Según 9 financiadores declarados.
Publicación
- Publicado
- 2017-09-12 · J Card Fail · vol. 24 · número 2 · págs. 65–73
- Editorial
- Elsevier BV
- Citado
- 52 citas · más que el 98% de estudios similares · 9.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Cardiovascular and exercise physiology · Nitric Oxide and Endothelin Effects · Muscle metabolism and nutrition
- Palabras clave
- dietary nitrate, heart failure with reduced ejection fraction, peak oxygen uptake, exercise capacity, beetroot juice, nitric oxide, exercise efficiency, ventilation, time to exhaustion, nitrite, dyspnea
- MeSH
- humans, nitrites, oxygen, stroke volume, follow-up studies, cross-over studies, double-blind method, oxygen consumption, respiration, exercise tolerance, dietary supplements, middle aged, female, male, heart failure
12 autores
- Andrew R. Coggan🇺🇸 · autor de correspondenciaWashington University in St. Louis; Indiana University Indianapolis; Indiana University – Purdue University Indianapolis
- Seth R. Broadstreet🇺🇸Indiana University – Purdue University Indianapolis
- Kiran Mahmood🇺🇸Washington University in St. Louis
- Deana Mikhalkova🇺🇸Washington University in St. Louis
- Michael Madigan🇺🇸Washington University in St. Louis
- Indra Bole🇺🇸Washington University in St. Louis
- Soohyung Park🇺🇸Washington University in St. Louis
- Joshua L. Leibowitz🇺🇸Washington University in St. Louis
- Ana Kadkhodayan🇺🇸Washington University in St. Louis
- Deepak P. Thomas🇺🇸Washington University in St. Louis
- Dakkota Thies🇺🇸Washington University in St. Louis
- Linda R. Peterson🇺🇸Washington University in St. Louis
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Patients with heart failure with reduced ejection fraction (HFrEF) exhibit lower efficiency, dyspnea, and diminished peak oxygen uptake (VO2peak) during exercise. Dietary nitrate (NO3-), a source of nitric oxide (NO), has improved these measures in some studies of other populations. We determined the effects of acute NO3- ingestion on exercise responses in 8 patients with HFrEF using a randomized, double-blind, placebo-controlled, crossover design.
Methods and results
Plasma NO3-, nitrite (NO2-), and breath NO were measured at multiple time points and respiratory gas exchange was determined during exercise after ingestion of beetroot juice containing or devoid of 11.2 mmol of NO3-. NO3- intake increased (P 3- and NO2- and breath NO by 1469 ± 245%, 105 ± 34%, and 60 ± 18%, respectively. Efficiency and ventilation during exercise were unchanged. However, NO3- ingestion increased (P 2peak by 8 ± 2% (ie, from 21.4 ± 2.1 to 23.0 ± 2.3 mL.min-1.kg-1). Time to fatigue improved (P < .05) by 7 ± 3 % (ie, from 582 ± 84 to 612 ± 81 seconds).
Conclusions
Acute dietary NO3- intake increases VO2peak and performance in patients with HFrEF. These data, in conjunction with our recent data demonstrating that dietary NO3- also improves muscle contractile function, suggest that dietary NO3- supplementation may be a valuable means of enhancing exercise capacity in this population.
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