Effects of dietary nitrate supplementation on the response to extremity cooling and endothelial function in individuals with cold sensitivity. A double blind, placebo controlled, crossover, randomised control trial
Eglin CM, Costello JT, Bailey SJ, Gilchrist M, Massey H, Shepherd AI
Nitric oxide : biology and chemistry · 24 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Portsmouth
- Gobierno
- National Institute for Health and Care Research
- Gobierno
- National Institute for Health Research (NIHR)
- Subvenciones
- National Institute for Health and Care Research (CL-2011-23-001)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2017-09-21 · Nitric Oxide · vol. 70 · págs. 76–85
- Editorial
- Elsevier BV
- Citado
- 25 citas · más que el 76% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 75 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY-NC-ND
- Áreas de investigación
- Nitric Oxide and Endothelin Effects · Thermoregulation and physiological responses · Cardiovascular Health and Disease Prevention
- Palabras clave
- dietary nitrate, beetroot juice, cold sensitivity, endothelial function, nitric oxide bioavailability, plasma nitrite, cutaneous vascular conductance, acetylcholine iontophoresis, blood pressure
- MeSH
- foot, forearm, fingers, endothelium, vascular, humans, beta vulgaris, nitrates, nitrites, acetylcholine, rewarming, cross-over studies, double-blind method, blood pressure, regional blood flow, dietary supplements, adult, middle aged, female, male, cold temperature, fruit and vegetable juices
6 autores
- Clare Eglin🇬🇧University of Portsmouth
- Joseph T. Costello🇬🇧University of Portsmouth
- Stephen J. Bailey🇬🇧Loughborough University
- Mark Gilchrist🇬🇧University of Exeter; Royal Devon and Exeter Hospital; NIHR Exeter Clinical Research Facility
- Heather C. Massey🇬🇧University of Portsmouth
- Anthony I. Shepherd🇬🇧 · autor de correspondenciaUniversity of Portsmouth
Resumen
El texto original del estudio, en el idioma en que se publicó.
Individuals with cold sensitivity have low peripheral skin blood flow and skin temperature possibly due to reduced nitric oxide (NO•) bioavailability. Beetroot has a high concentration of inorganic nitrate and may increase NO-mediated vasodilation. Using a placebo-controlled, double blind, randomised, crossover design, this study tested the hypotheses that acute beetroot supplementation would increase the rate of cutaneous rewarming following a local cold challenge and augment endothelium-dependent vasodilation in cold sensitive individuals. Thirteen cold sensitive participants completed foot and hand cooling (separately, in 15 °C water for 2 min) with spontaneous rewarming in 30 °C air whilst skin temperature and cutaneous vascular conductance (CVC) were measured (Baseline). On two further separate visits, participants consumed 140 ml of either concentrated beetroot juice (nitrate supplementation) or nitrate-depleted beetroot juice (Placebo) 90 min before resting seated blood pressure was measured. Endothelial function was assessed by measuring CVC at the forearm, finger and foot during iontophoresis of 1% w/v acetylcholine followed by foot and hand cooling as for Baseline. Plasma nitrite concentrations significantly increased in nitrate supplementation compared to Placebo and Baseline (502 ± 246 nmol L-1; 73 ± 45 nmol L-1; 74 ± 49 nmol L-1 respectively; n = 11; P 0.05). Nitrate supplementation did not alter endothelial function in the forearm, finger or foot (all P > 0.05) compared to Placebo. Despite a physiologically meaningful rise in plasma nitrite concentrations, acute nitrate supplementation does not alter extremity rewarming, endothelial function or blood pressure in individuals with cold sensitivity.
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