Plasma 25-hydroxyvitamin D levels, vitamin D intake, and pancreatic cancer risk or mortality: a meta-analysis
Zhang X, Huang XZ, Chen WJ, Wu J, Chen Y, Wu CC, Wang ZN
Oncotarget · 33 citas
Cómo se estudió
- Diseño
- Metaanálisis (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Wenzhou Medical University
- Universidad u hospital
- China Medical University
- Universidad u hospital
- Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-06-29 · Oncotarget · vol. 8 · número 38 · págs. 64395–64406
- Editorial
- Impact Journals LLC
- Citado
- 44 citas · más que el 68% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 82 trabajos
- Acceso
- Acceso abierto (publicación gratuita) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Vitamin C and Antioxidants Research · GDF15 and Related Biomarkers
- Palabras clave
- Medicine, Vitamin D and neurology, Meta-analysis, Pancreatic cancer, Internal medicine, Cancer, Oncology, Endocrinology, Gastroenterology
7 autores
- Xi Zhang🇨🇳 · autor de correspondenciaWenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- Xuanzhang Huang🇨🇳 · autor de correspondenciaWenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- Wen-jun Chen🇨🇳Wenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- Jian Wu🇨🇳Wenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- You Chen
- Cong-cong Wu🇨🇳Wenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- Zhen-Ning Wang🇨🇳Wenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University; First Hospital of China Medical University; China Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The associations between vitamin D status, including plasma 25-hydroxyvitamin D [25(OH)D] levels and vitamin D intake, and pancreatic cancer risk and mortality are inconsistent. The aims of this study are to evaluate the antitumor and therapeutic effects of vitamin D status for pancreatic cancer patients.
Methods
A literature search for relevant studies was conducted using PubMed and Embase databases. Risk ratio (RR), hazard ratio (HR), and 95% confidence interval (CI) were used as the effect measures. All statistical analyses were performed using Stata software 12.0.
Results
Our results indicated that high plasma 25(OH)D levels were inversely associated with pancreatic cancer mortality without significant heterogeneity (HR=0.81, 95% CI=0.68-0.96). However, high plasma 25(OH)D levels could not reduce pancreatic cancer risk (RR=1.02, 95% CI=0.66-1.57). Moreover, vitamin D intake was also not associated with pancreatic cancer risk (RR=1.11, 95% CI=0.67-1.86).
Conclusions
Our results indicate that high plasma 25(OH)D levels were significantly associated with improved survival in pancreatic cancer patients. However, there were no significant associations between vitamin D intake or plasma 25(OH)D levels and pancreatic cancer risk.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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