Financiado en parte por Novo Nordisk, Novo Nordisk Fonden
Vitamin D Stored in Fat Tissue During a 5-Year Intervention Affects Serum 25-Hydroxyvitamin D Levels the Following Year
Martinaityte I, Kamycheva E, Didriksen A, Jakobsen J, Jorde R
The Journal of clinical endocrinology and metabolism · 57 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- Universitetet i Tromsø
- Empresa
- Novo Nordisk
- Gobierno
- Norges Forskningsråd
- Organización sin fines de lucro
- Diabetesforbundet
- Empresa
- Novo Nordisk Fonden
- Subvenciones
- Norges Forskningsråd (184766); Novo Nordisk Fonden (NNF12OC1016126); Novo Nordisk (R195-A16126)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2017-07-26 · J Clin Endocrinol Metab · vol. 102 · número 10 · págs. 3731–3738
- Editorial
- Oxford University Press
- Citado
- 74 citas · más que el 94% de estudios similares · 3.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 26 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Adipokines, Inflammation, and Metabolic Diseases · HIV-related health complications and treatments
- Palabras clave
- Vitamin D and neurology, Vitamin, Intervention (counseling), Medicine, Physiology, Internal medicine, Endocrinology, Chemistry, Nursing
- MeSH
- adipose tissue, humans, diabetes mellitus, type 2, vitamin d deficiency, vitamin d, placebos, follow-up studies, double-blind method, time factors, dietary supplements, aged, aged, 80 and over, middle aged, female, male
5 autores
- Ieva Martinaityte🇳🇴 · autor de correspondenciaUniversity Hospital of North Norway; UiT The Arctic University of Norway
- Elena Kamycheva🇳🇴University Hospital of North Norway; UiT The Arctic University of Norway
- Allan Didriksen🇳🇴UiT The Arctic University of Norway
- Jette Jakobsen🇩🇰Technical University of Denmark
- Rolf Jorde🇳🇴University Hospital of North Norway; UiT The Arctic University of Norway
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Vitamin D and 25-hydroxyvitamin D [25(OH)D] are stored in adipose tissue, but the clinical relevance is uncertain.
Objective
To evaluate changes in serum 25(OH)D and adipose tissue vitamin D levels after stopping vitamin D supplementation.
Design
A prospective, double-blind cohort follow-up study.
Setting
Clinical Research Unit at University Hospital of North Norway.
Patients
Seventy-six subjects were included after participation in a 3- to 5-year prevention of type 2 diabetes study and were administered 20,000 IU of vitamin D or placebo per week.
Intervention
During the 12-month follow-up period, blood samples were drawn at the beginning and after 1, 3, 6, 9, and 12 months. Fat biopsies were taken at the start and end.
Main outcome measures
Changes in 25(OH)D level in serum and 25(OH)D and vitamin D levels in adipose tissue.
Results
Forty-one of 42 subjects who were given vitamin D and 33 of 34 subjects who were given placebo completed the study. At the inclusion, mean serum 25(OH)D levels were 122 and 71 nmol/L in the vitamin D and placebo groups, respectively. Serum 25(OH)D levels were significantly higher in the vitamin D group than in the placebo group throughout and were 84.5 and 73.1 nmol/L, respectively, after 12 months. In the vitamin D group, adipose tissue vitamin D levels decreased by 52% over 12 months.
Conclusion
Vitamin D and 25(OH)D stored in adipose tissue after 3 to 5 years of vitamin D supplementation may have a clinically relevant effect on serum 25(OH)D level the following year.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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