Magnesium Intake, Quality of Carbohydrates, and Risk of Type 2 Diabetes: Results From Three U.S. Cohorts
Hruby A, Guasch-Ferré M, Bhupathiraju SN, Manson JE, Willett WC, McKeown NM, Hu FB
Diabetes care · 30 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Agricultural Research Service
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NCI NIH HHS
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NIDDK
- Subvenciones
- National Heart, Lung, and Blood Institute (HL60712); National Cancer Institute (P01 CA055075.); National Cancer Institute (P01 CA087969); National Institute of Diabetes and Digestive and Kidney Diseases (K01 DK107804); National Cancer Institute (UM1 CA186107); National Cancer Institute (UM1-CA-167552); National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK058845); National Cancer Institute (UM1 CA176726); Agricultural Research Service (58-1950-4-003); National Heart, Lung, and Blood Institute (R01 HL060712); National Institute of Diabetes and Digestive and Kidney Diseases (DK58845); National Cancer Institute ([P01 CA87969)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2017-10-04 · Diabetes Care · vol. 40 · número 12 · págs. 1695–1702
- Editorial
- American Diabetes Association
- Citado
- 48 citas · más que el 88% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Food composition and properties
- Palabras clave
- Medicine, Type 2 diabetes, Diabetes mellitus, Glycemic index, Context (archaeology), Glycemic, Internal medicine, Hazard ratio, Endocrinology, Lower risk, Confidence interval
- MeSH
- humans, diabetes mellitus, type 2, magnesium, dietary carbohydrates, blood glucose, diet, multivariate analysis, proportional hazards models, risk factors, longitudinal studies, follow-up studies, energy intake, glycemic index, dietary fiber, dietary supplements, adult, middle aged, nurses, united states, female, male, food quality
7 autores
- Adela Hruby🇺🇸 · autor de correspondenciaTufts University; Harvard University; Jean Mayer Human Nutrition Research Center on Aging
- Marta Liu Guasch-Ferré🇺🇸 · autor de correspondenciaHarvard University
- Shilpa N Bhupathiraju🇺🇸Brigham and Women's Hospital; Harvard University
- JoAnn E. Manson🇺🇸Brigham and Women's Hospital; Harvard University
- Walter Churchill Willett🇺🇸Brigham and Women's Hospital; Harvard University
- Nicola Mary McKeown🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- Frank B. Hu🇺🇸Brigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Magnesium intake is inversely associated with risk of type 2 diabetes in many observational studies, but few have assessed this association in the context of the carbohydrate quality of the diet. We hypothesized that higher magnesium intake is associated with lower risk of type 2 diabetes, especially in the context of a poor carbohydrate-quality diet characterized by low cereal fiber or high glycemic index (GI) or glycemic load (GL).
Research design and methods
In the Nurses' Health Study (NHS; 1984-2012, n = 69,176), NHS2 (1991-2013, n = 91,471), and the Health Professionals' Follow-Up Study (1986-2012, n = 42,096), dietary intake was assessed from food frequency questionnaires every 4 years. Type 2 diabetes was ascertained by biennial and supplementary questionnaires. We calculated multivariate hazard ratios (HRs) of magnesium intake and incident diabetes, adjusted for age, BMI, family history of diabetes, physical activity, smoking, hypertension, hypercholesterolemia, GL, energy intake, alcohol, cereal fiber, polyunsaturated fats, trans fatty acids, and processed meat, and we considered the joint associations of magnesium and carbohydrate quality on diabetes risk.
Results
We documented 17,130 incident cases of type 2 diabetes over 28 years of follow-up. In pooled analyses across the three cohorts, those with the highest magnesium intake had 15% lower risk of type 2 diabetes compared with those with the lowest intake (pooled multivariate HR in quintile 5 vs. 1: 0.85 [95% CI 0.80-0.91], P P interaction <0.001).
Conclusions
Higher magnesium intake is associated with lower risk of type 2 diabetes, especially in the context of lower carbohydrate-quality diets.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.