Modulation of the gut microbiota by the mixture of fish oil and krill oil in high-fat diet-induced obesity mice
Cui C, Li Y, Gao H, Zhang H, Han J, Zhang D, Li Y, Zhou J, Lu C, Su X
PloS one · 51 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Ningbo University
- Sin clasificar
- Nature
- Universidad u hospital
- K. C. Wong Magna Fund in Ningbo University
- Universidad u hospital
- Talent project in Ningbo University
- Universidad u hospital
- K.C.Wong Magna Fund in Ningbo University
- Gobierno
- Key Specialty of Ningbo City
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-10-09 · PLoS One · vol. 12 · número 10 · pág. e0186216
- Editorial
- Public Library of Science
- Citado
- 70 citas · más que el 94% de estudios similares · 3.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 80 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Gut microbiota and health · Diet and metabolism studies · Nutritional Studies and Diet
- Palabras clave
- Gut flora, Obesity, Fish oil, Triglyceride, Krill, Biology, Food science, Fatty liver, Internal medicine, Endocrinology, Cholesterol, Physiology, Biochemistry, Fish <Actinopterygii>, Medicine, Ecology, Fishery
- MeSH
- liver, animals, humans, mice, mice, obese, euphausiacea, obesity, cholesterol, triglycerides, lipoproteins, ldl, fish oils, diet, high-fat, gastrointestinal microbiome
10 autores
- Chenxi Cui🇨🇳Ningbo University
- Yanyan Li🇨🇳🇺🇸Ningbo University; Cornell University
- Hang Gao🇨🇳First Bethune Hospital of Jilin University
- Hongyan Zhang🇨🇳Ningbo University
- Jiaojiao Han🇨🇳Ningbo University
- Dijun Zhang🇨🇳Ningbo University
- Ye Li🇨🇳🇺🇸Ningbo University; Cornell University
- Jun Zhou🇨🇳Ningbo University
- Chenyang Lu🇨🇳 · autor de correspondenciaNingbo University
- Xiurong Su🇨🇳 · autor de correspondenciaNingbo University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Previous studies confirmed that dietary supplements of fish oil and krill oil can alleviate obesity in mice, but the underlying mechanism remains unclear. This study aims to discern whether oil treatment change the structure of the gut microbiota during the obesity alleviation. The ICR mice received high-fat diet (HFD) continuously for 12 weeks after two weeks of acclimatization with a standard chow diet, and the mice fed with a standard chow diet were used as the control. In the groups that received HFD with oil supplementation, the weight gains were attenuated and the liver index, total cholesterol, triglyceride and low-density lipoprotein cholesterol were reduced stepwise compared with the HFD group, and the overall structure of the gut microbiota, which was modulated in the HFD group, was shifted toward the structure found in the control group. Moreover, eighty-two altered operational taxonomic units responsive to oil treatment were identified and nineteen of them differing in one or more parameters associated with obesity. In conclusion, this study confirmed the effect of oil treatment on obesity alleviation, as well as on the microbiota structure alterations. We proposed that further researches are needed to elucidate the causal relationship between obesity alleviation and gut microbiota modulation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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