Blueberry supplementation attenuates oxidative stress within monocytes and modulates immune cell levels in adults with metabolic syndrome: a randomized, double-blind, placebo-controlled trial
Nair AR, Mariappan N, Stull AJ, Francis J
Food & function · 43 citas
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Alimentación controladaFinanciación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2017-01-01 · Food Funct · vol. 8 · número 11 · págs. 4118–4128
- Editorial
- Royal Society of Chemistry
- Citado
- 65 citas · más que el 82% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 54 trabajos
- Acceso
- De pago
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Exercise and Physiological Responses · Adipokines, Inflammation, and Metabolic Diseases
- Palabras clave
- metabolic syndrome, oxidative stress, monocytes, dendritic cells, myeloid dendritic cells, inflammation, immunomodulation, reactive oxygen species, superoxide, TNF-α, interleukin-6, TLR4, GM-CSF, cytokine gene expression
- MeSH
- monocytes, humans, reactive oxygen species, tumor necrosis factor-alpha, plant extracts, interleukin-6, double-blind method, oxidative stress, dietary supplements, adult, middle aged, female, male, blueberry plants, metabolic syndrome
4 autores
- Anand R. Nair🇺🇸Louisiana State University
- Nithya Mariappan🇺🇸Louisiana State University; University of Alabama at Birmingham; UAB Medicine
- April J. Stull🇺🇸🇬🇧Pennington Biomedical Research Center; Louisiana State University System; University of Maryland Eastern Shore; Princess Anne Hospital
- Joseph Francis🇺🇸 · autor de correspondenciaLouisiana State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Blueberries (BB) have been shown to improve insulin sensitivity and endothelial function in obese and pre-diabetic humans, and decrease oxidative stress and inflammation, and ameliorate cardio-renal damage in rodents. This indicates that blueberries have a systemic effect and are not limited to a particular organ system. In order for blueberries to exert beneficial effects on the whole body, the mechanism would logically have to operate through modulation of cellular humoral factors.
Objective
This study investigated the role of blueberries in modulating immune cell levels and attenuating circulatory and monocyte inflammation and oxidative stress in metabolic syndrome (MetS) subjects.
Design
A double-blind, randomized and placebo-controlled study was conducted in adults with MetS, in which they received a blueberry (22.5 g freeze-dried) or placebo smoothie twice daily for six weeks. Free radical production in the whole blood and monocytes, dendritic cell (DC) levels, expression of cytokines in monocytes and serum inflammatory markers were assessed pre- and post-intervention.
Results
Baseline free radical levels in MetS subjects' samples were not different between groups. Treatment with blueberries markedly decreased superoxide and total reactive oxygen species (ROS) in whole blood and monocytes compared to the placebo (p ≤ 0.05). The baseline DC numbers in MetS subjects' samples in both groups were not different, however treatment with blueberries significantly increased myeloid DC (p ≤ 0.05) and had no effect on plasmacytoid cells. Blueberry treatment decreased monocyte gene expression of TNFα, IL-6, TLR4 and reduced serum GMCSF in MetS subjects when compared to the placebo treatment (p ≤ 0.05).
Conclusions
The findings of the current study demonstrate that blueberries exert immunomodulatory effects and attenuate oxidative stress and inflammation in adults with MetS.
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