Blueberry Metabolites Attenuate Lipotoxicity-Induced Endothelial Dysfunction
Bharat D, Cavalcanti RRM, Petersen C, Begaye N, Cutler BR, Costa MMA, Ramos RKLG, Ferreira MR, Li Y, Bharath LP, Toolson E, Sebahar P, Looper RE, Jalili T, Rajasekaran NS, Jia Z, Symons JD, Anandh Babu PV
Molecular nutrition & food research · 60 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio in vitro o de mecanismos (clasificado por nuestro filtro de IA)
- Estudiado en
- Células o muestras de laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Heart Association
- Universidad u hospital
- University of Utah
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Aging
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NIA NIH HHS
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Institute on Aging (R03AG042860); National Heart, Lung, and Blood Institute (R01HL118067); National Heart, Lung, and Blood Institute (R01HL141540); American Heart Association ((AHA:16GRNT31050004)); National Institute on Aging (R03 AG052848); National Institutes of Health (RO3AGO52848); National Institutes of Health (AG042860); National Institutes of Health (HL118067)
Según 7 financiadores declarados.
Publicación
- Publicado
- 2017-10-12 · Mol Nutr Food Res · vol. 62 · número 2
- Editorial
- Wiley
- Citado
- 78 citas · más que el 94% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Plant Gene Expression Analysis · Biological and pharmacological studies of plants
- Palabras clave
- Chemistry, Lipotoxicity, Endothelial dysfunction, Nitric oxide, Reactive oxygen species, Biochemistry, Endothelium, Pharmacology, Vanillic acid, Food science, Endocrinology, Medicine, Diabetes mellitus
- MeSH
- aorta, endothelium, vascular, cells, cultured, endothelial cells, animals, mice, inbred c57bl, humans, nitric oxide, reactive oxygen species, anthocyanins, insulin, palmitic acid, gene expression regulation, male, blueberry plants
18 autores
- Divya Bharat🇺🇸University of Utah
- Rafaela Ramos Mororo Cavalcanti🇺🇸University of Utah
- Chrissa Petersen🇺🇸University of Utah
- Nathan Begaye🇺🇸University of Utah
- Brett Ronald Cutler🇺🇸University of Utah
- Marcella Melo Assis Costa🇺🇸University of Utah
- Renata Kelly Luna Gomes Ramos🇺🇸University of Utah
- Marina Ramos Ferreira🇺🇸University of Utah
- Youyou Li🇺🇸University of Utah
- Leena P. Bharath🇺🇸University of Utah
- Emma Toolson🇺🇸University of Utah
- Paul R. Sebahar🇺🇸University of Utah
- Ryan Looper🇺🇸University of Utah
- Thunder Jalili🇺🇸University of Utah
- Namakkal Soorappan Rajasekaran🇺🇸University of Alabama at Birmingham
- Zhenquan Jia🇺🇸University of North Carolina at Greensboro
- J. David Symons🇺🇸University of Utah
- Pon Velayutham Anandh Babu🇺🇸 · autor de correspondenciaUniversity of Utah
Resumen
El texto original del estudio, en el idioma en que se publicó.
Scope
Lipotoxicity-induced endothelial dysfunction is an important vascular complication associated with diabetes. Clinical studies support the vascular benefits of blueberry anthocyanins, but the underlying mechanism is unclear. The hypothesis that metabolites of blueberry anthocyanins attenuate lipotoxicity-induced endothelial dysfunction was tested.
Methods and results
Human aortic endothelial cells (HAECs) were treated for 6 h with either: (i) the parent anthocyanins (malvidin-3-glucoside and cyanidin-3-glucoside); or (ii) the blueberry metabolites (hydroxyhippuric acid, hippuric acid, benzoic acid-4-sulfate, isovanillic acid-3-sulfate, and vanillic acid-4-sulfate), at concentrations known to circulate in humans following blueberry consumption. For the last 5 h HAECs were treated with palmitate or vehicle. HAECs treated with palmitate displayed elevated reactive oxygen species generation, increased mRNA expression of NOX4, chemokines, adhesion molecules, and IκBα, exaggerated monocyte binding, and suppressed nitric oxide production. Of note, the damaging effects of palmitate were ameliorated in HAECs treated with blueberry metabolites but not parent anthocyanins. Further, important translational relevance of these results was provided by our observation that palmitate-induced endothelial dysfunction was lessened in arterial segments that incubated concurrently with blueberry metabolites.
Conclusion
The presented findings indicate that the vascular benefits of blueberry anthocyanins are mediated by their metabolites. Blueberries might complement existing therapies to lessen vascular complications.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.