Sulforaphane and Epigallocatechin Gallate Restore Estrogen Receptor Expression by Modulating Epigenetic Events in the Breast Cancer Cell Line MDA-MB-231: A Systematic Review and Meta-Analysis
Gianfredi V, Vannini S, Moretti M, Villarini M, Bragazzi NL, Izzotti A, Nucci D
Journal of nutrigenetics and nutrigenomics · 30 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Células o muestras de laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2017-01-01 · J Nutrigenet Nutrigenomics · vol. 10 · número 3-4 · págs. 126–135
- Editorial
- Karger Publishers
- Citado
- 42 citas · más que el 52% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 30 trabajos
- Acceso
- Acceso abierto (revista)
- Áreas de investigación
- Epigenetics and DNA Methylation · Genomics, phytochemicals, and oxidative stress · Tea Polyphenols and Effects
- Palabras clave
- sulforaphane, epigallocatechin gallate, estrogen receptor, breast cancer, MDA-MB-231 cells, epigenetic modulation, histone acetylation, dietary polyphenols, isothiocyanates, apoptosis, tumor growth inhibition, chemoprevention
- MeSH
- cell line, tumor, humans, breast neoplasms, isothiocyanates, sulfoxides, catechin, receptors, estrogen, anticarcinogenic agents, apoptosis, gene expression, epigenesis, genetic, female, nutrigenomics
7 autores
- Vincenza Gianfredi🇮🇹University of Perugia
- Samuele Vannini🇮🇹University of Perugia
- Massimo Moretti🇮🇹University of Perugia
- Milena Villarini🇮🇹University of Perugia
- Nicola Luigi Bragazzi🇮🇹University of Genoa
- Alberto Izzotti🇮🇹University of Genoa
- Daniele Nucci🇮🇹Istituto Oncologico Veneto
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/aims
Epigenetics refers to modifications in gene activity and expression without alteration at the DNA sequence. Environment and diet could influence gene expression. Diet modifications may be meaningful in preventing and treating chronic diseases, cancer included. Dietary bioactive compounds, such as polyphenols (e.g., curcumin, resveratrol, or epigallocatechin gallate [EGCG]) or isothiocyanate (e.g., sulforaphane [SFN]), can regulate histone acetylation. The aim of this systematic review and meta-analysis was to evaluate the effect of SFN and EGCG on breast cancer (BC) cells cultured in vitro.
Methods
Due to the enormous variability observed in study protocols and the innumerable genes involved, only studies analyzing the number of apoptotic cells in the MDA-MB-231 cell line were evaluated. The effect size (ES) was computed as the ratio of means.
Results
We identified 7 studies, 4 regarding the effect of 10 µM SFN on MDA-MB-231 cells (ES = 4.59, 95% confidence interval 4.05-5.20) and 3 focusing on the impact of 20 µM EGCG (ES = 2.84, 95% confidence interval 2.60-3.10).
Conclusion
The findings suggest beneficial effects of dietary bioactive compounds such as SFN and EGCG and their effect on BC cells by restoring estrogen receptor gene expression, modulating epigenetic changes and events, and interfering with tumor growth rate. Publication bias limits the generalizability of the conclusions. High-quality studies are needed.
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