Effects of dietary nitrate on respiratory physiology at high altitude - Results from the Xtreme Alps study
Cumpstey AF, Hennis PJ, Gilbert-Kawai ET, Fernandez BO, Poudevigne M, Cobb A, Meale P, Mitchell K, Moyses H, Pöhnl H, Mythen MG, Grocott MPW, Feelisch M, Martin DS, Xtreme Alps research group
Nitric oxide : biology and chemistry · 17 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- National Institute for Health and Care Research
- Universidad u hospital
- University of Southampton
- Universidad u hospital
- University College London
- Gobierno
- Medical Research Council
- Gobierno
- National Institute for Health Research (NIHR)
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- Medical Research Council (MR/P008887/1); National Institute for Health and Care Research (ACF-2015-26-003)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-10-16 · Nitric Oxide · vol. 71 · págs. 57–68
- Editorial
- Elsevier BV
- Citado
- 17 citas · más que el 84% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 74 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- High Altitude and Hypoxia · Neuroscience of respiration and sleep · Chronic Obstructive Pulmonary Disease (COPD) Research
- Palabras clave
- Nitrate, Nitrite, Exhaled breath condensate, Effects of high altitude on humans, Nitric oxide, Placebo, Hypoxia (environmental), Saliva, Exhaled nitric oxide, Animal science, Altitude (triangle), Altitude sickness, Chemistry, Internal medicine, Physiology, Medicine, Oxygen, Biology, Spirometry, Pathology
- MeSH
- lung, saliva, humans, beta vulgaris, altitude sickness, nitrates, nitrites, oxygen, nitric oxide, dietary supplements, adult, female, male, respiratory rate, fruit and vegetable juices
14 autores
- Andrew F. Cumpstey🇬🇧Southampton General Hospital; University Hospital Southampton NHS Foundation Trust; NIHR Southampton Respiratory Biomedical Research Unit; University of Southampton
- Philip J Hennis🇬🇧University College London
- Edward T. Gilbert-Kawai🇬🇧University College London
- Bernadette O. Fernandez🇬🇧University Hospital Southampton NHS Foundation Trust; University of Warwick; NIHR Southampton Biomedical Research Centre; University of Southampton
- Matthieu Poudevigne🇬🇧University Hospital Southampton NHS Foundation Trust; NIHR Southampton Biomedical Research Centre; University of Southampton
- Alexandra Cobb🇬🇧University College London
- Paula Meale🇬🇧University College London
- Kay Mitchell🇬🇧Southampton General Hospital; University Hospital Southampton NHS Foundation Trust; NIHR Southampton Respiratory Biomedical Research Unit; University of Southampton
- Helen E. Moyses🇬🇧University Hospital Southampton NHS Foundation Trust; NIHR Southampton Biomedical Research Centre; University of Southampton
- Helmut Pöhnl
- Monty G. Mythen🇬🇧University College London
- Michael P. W. Grocott🇬🇧Southampton General Hospital; University Hospital Southampton NHS Foundation Trust; NIHR Southampton Respiratory Biomedical Research Unit; University of Southampton
- Martin Feelisch🇬🇧 · autor de correspondenciaSouthampton General Hospital; University Hospital Southampton NHS Foundation Trust; University of Warwick; NIHR Southampton Respiratory Biomedical Research Unit; NIHR Southampton Biomedical Research Centre; University of Southampton
- DANIEL S. MARTIN🇬🇧 · autor de correspondenciaEnglish Institute of Sport; University College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Nitric oxide (NO) production plays a central role in conferring tolerance to hypoxia. Tibetan highlanders, successful high-altitude dwellers for millennia, have higher circulating nitrate and exhaled NO (ENO) levels than native lowlanders. Since nitrate itself can reduce the oxygen cost of exercise in normoxia it may confer additional benefits at high altitude. Xtreme Alps was a double-blinded randomised placebo-controlled trial to investigate how dietary nitrate supplementation affects physiological responses to hypoxia in 28 healthy adult volunteers resident at 4559 m for 1 week; 14 receiving a beetroot-based high-nitrate supplement and 14 receiving a low-nitrate 'placebo' of matching appearance/taste. ENO, vital signs and acute mountain sickness (AMS) severity were recorded at sea level (SL) and daily at altitude. Moreover, standard spirometric values were recorded, and saliva and exhaled breath condensate (EBC) collected. There was no significant difference in resting cardiorespiratory variables, peripheral oxygen saturation or AMS score with nitrate supplementation at SL or altitude. Median ENO levels increased from 1.5/3.0 mPa at SL, to 3.5/7.4 mPa after 5 days at altitude (D5) in the low and high-nitrate groups, respectively (p = 0.02). EBC nitrite also rose significantly with dietary nitrate (p = 0.004), 1.7-5.1 μM at SL and 1.6-6.3 μM at D5, and this rise appeared to be associated with increased levels of ENO. However, no significant changes occurred to levels of EBC nitrate or nitrosation products (RXNO). Median salivary nitrite/nitrate concentrations increased from 56.5/786 μM to 333/5,194 μM with nitrate supplementation at SL, and changed to 85.6/641 μM and 341/4,553 μM on D5. Salivary RXNO rose markedly with treatment at SL from 0.55 μM to 5.70 μM. At D5 placebo salivary RXNO had increased to 1.90 μM whilst treatment RXNO decreased to 3.26 μM. There was no association with changes in any observation variables or AMS score. In conclusion, dietary nitrate supplementation is well tolerated at altitude and significantly increases pulmonary NO availability and both salivary and EBC NO metabolite concentrations. Surprisingly, this is not associated with changes in hemodynamics, oxygen saturation or AMS development.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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