The effects of EPA and DHA enriched fish oil on nutritional and immunological markers of treatment naïve breast cancer patients: a randomized double-blind controlled trial
Paixão EMDS, Oliveira ACM, Pizato N, Muniz-Junqueira MI, Magalhães KG, Nakano EY, Ito MK
Nutrition journal · 70 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Gobierno
- Fundação de Apoio à Pesquisa do Distrito Federal
- Subvenciones
- Fundação de Apoio à Pesquisa do Distrito Federal (0193.000.557/2009)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-10-23 · Nutr J · vol. 16 · número 1 · pág. 71
- Editorial
- BioMed Central
- Citado
- 91 citas · más que el 94% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Coconut Research and Applications · Natural Products and Biological Research
- Palabras clave
- Fish oil, Medicine, Docosahexaenoic acid, Eicosapentaenoic acid, Clinical nutrition, Internal medicine, Breast cancer, Gastroenterology, Polyunsaturated fatty acid, Proinflammatory cytokine, Randomized controlled trial, Endocrinology, Cancer, Inflammation, Fatty acid, Biochemistry, Biology, Fish <Actinopterygii>
- MeSH
- cd4-positive t-lymphocytes, humans, breast neoplasms, docosahexaenoic acids, eicosapentaenoic acid, dinoprostone, fish oils, c-reactive protein, cytokines, diet, double-blind method, nutritional status, socioeconomic factors, adolescent, adult, aged, middle aged, female, young adult, biomarkers
7 autores
- Elemárcia Martins da Silva Paixão🇧🇷 · autor de correspondenciaUniversidade de Brasília
- Ana Carolina de M. Oliveira🇧🇷Universidade de Brasília
- Nathalia Pizato🇧🇷Universidade de Brasília
- Maria Imaculada Muniz‐Junqueira🇧🇷Universidade de Brasília
- Kelly Grace Magalhães🇧🇷Universidade de Brasília
- Eduardo Yoshio Nakano🇧🇷Universidade de Brasília
- Marina Ito🇧🇷Universidade de Brasília
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
We evaluated the effects of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids enriched fish oil (FO) on nutritional and immunological parameters of treatment naïve breast cancer patients.
Methods
In a randomized double blind controlled trial, the FO group (FG) patients were supplemented with 2 g/ day of FO concentrate containing 1.8 g of n-3 fatty acids during 30 days. The placebo group (PG) received 2 g/ day of mineral oil. At baseline and after the intervention, plasma levels of n-3 fatty acids, dietary intake, weight, body composition, biochemical and immunological markers were assessed.
Results
At the end of the intervention period, no between group differences were observed regarding anthropometric parameters. There was a significant increase in the plasma phospholipid EPA (p = 0.004), DHA (p = 0.007) of the FG patients. In FG patients the percentages of peripheral blood CD4+ T lymphocytes and serum high sensitivity C-reactive protein (hsCRP) levels were maintained while in PG patients there was a significant increase in hsCRP (p = 0.024). We also observed a significant reduction in the percentage of CD4+ T lymphocytes in the peripheral blood (p = 0.042) of PG patients. No changes in serum proinflammatory cytokine and prostaglandin E2 levels were observed.
Conclusions
Supplementation of newly diagnosed breast cancer patients with EPA and DHA led to a significant change in the composition of plasma fatty acids, maintained the level of CD4+ T cells and serum levels of hsCRP, suggestive of a beneficial effect on the immune system and less active inflammatory response.
Trial registration
Brazilian Clinical Trials Registry (REBEC): RBR-2b2hqh. Registered 29 April 2013, retrospectively registered.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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