Polyphenol- and Caffeine-Rich Postfermented Pu-erh Tea Improves Diet-Induced Metabolic Syndrome by Remodeling Intestinal Homeostasis in Mice
Gao X, Xie Q, Kong P, Liu L, Sun S, Xiong B, Huang B, Yan L, Sheng J, Xiang H
Infection and immunity · 80 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Jilin Province Science and Technology Institute of China
- Gobierno
- Jilin Province Development and Reform Commission of China
Según 2 financiadores declarados.
Publicación
- Publicado
- 2017-10-24 · Infect Immun · vol. 86 · número 1
- Editorial
- American Society for Microbiology
- Citado
- 128 citas · más que el 96% de estudios similares · 5.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 56 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Tea Polyphenols and Effects · Gut microbiota and health · Tryptophan and brain disorders
- Palabras clave
- Akkermansia muciniphila, Gut flora, Biology, Endocrinology, Akkermansia, Internal medicine, Diet-induced obese, Lipid metabolism, Metabolic syndrome, Thermogenesis, Brown adipose tissue, Faecalibacterium prausnitzii, Glucose homeostasis, White adipose tissue, Biochemistry, Adipose tissue, Insulin resistance, Lactobacillus, Obesity, Medicine, Fermentation
- MeSH
- intestines, liver, cell line, cell line, tumor, hela cells, animals, mice, inbred c57bl, humans, mice, endotoxemia, inflammation, caffeine, homeostasis, tea, male, lipid metabolism, hek293 cells, polyphenols, diet, high-fat, microbiota, gastrointestinal microbiome, metabolic syndrome
10 autores
- Xiaoyu Gao🇨🇳Jilin University; Puer University
- Qiuhong Xie🇨🇳Jilin University
- Ping Hao Kong🇨🇳Jilin University
- Ling Liu🇨🇳Jilin University
- Sheng Nan Sun🇨🇳Jilin University
- Boyu Xiong🇨🇳Jilin University
- Baojia Huang🇨🇳Jilin University
- Liang Yan🇨🇳Yunnan University; Puer University
- Jun Sheng🇨🇳Yunnan Agricultural University
- Hongyu Xiang🇨🇳Jilin University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Postfermented Pu-erh tea (PE) protects against metabolic syndrome (MS), but little is known regarding its underlying mechanisms. Animal experiments were performed to determine whether the gut microbiota mediated the improvement in diet-induced MS by PE and its main active components (PEAC). We confirmed that PE altered the body composition and energy efficiency, attenuated metabolic endotoxemia and systemic and multiple-tissue inflammation, and improved the glucose and lipid metabolism disorder in high-fat diet (HFD)-fed mice via multiple pathways. Notably, PE promoted the lipid oxidation and browning of white adipose tissue (WAT) in HFD-fed mice. Polyphenols and caffeine (CAF) played critical roles in improving these parameters. Meanwhile, PE remodeled the disrupted intestinal homeostasis that was induced by the HFD. Many metabolic changes observed in the mice were significantly correlated with alterations in specific gut bacteria. Akkermansia muciniphila and Faecalibacterium prausnitzii were speculated to be the key gut bacterial links between the PEAC treatment and MS at the genus and species levels. Interestingly, A. muciniphila administration altered body composition and energy efficiency, promoted the browning of WAT, and improved the lipid and glucose metabolism disorder in the HFD-fed mice, whereas F. prausnitzii administration reduced the HFD-induced liver and intestinal inflammatory responses. In summary, polyphenol- and CAF-rich PE improved diet-induced MS, and this effect was associated with a remodeling of the gut microbiota.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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