Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity
Norris JM, Lee HS, Frederiksen B, Erlund I, Uusitalo U, Yang J, Lernmark Å, Simell O, Toppari J, Rewers M, Ziegler AG, She JX, Onengut-Gumuscu S, Chen WM, Rich SS, Sundvall J, Akolkar B, Krischer J, Virtanen SM, Hagopian W, TEDDY Study Group
Diabetes · 85 citas
Cómo se estudió
- Diseño
- Estudio de casos y controles (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Centers for Disease Control and Prevention
- Gobierno
- National Institute of Allergy and Infectious Diseases
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Institute of Environmental Health Sciences
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Gobierno
- NIDDK NIH HHS
- Organización sin fines de lucro
- JDRF
- Gobierno
- NCATS NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (UC4-DK-112243); National Institute of Diabetes and Digestive and Kidney Diseases (HHSN267200700014C); National Institute of Diabetes and Digestive and Kidney Diseases (U01 DK63865); National Institute of Diabetes and Digestive and Kidney Diseases (UC4-DK-117483); National Institute of Diabetes and Digestive and Kidney Diseases (U01-DK-063829); National Center for Advancing Translational Sciences (UL 1 TR001082); National Institute of Diabetes and Digestive and Kidney Diseases (U01-DK-63821); National Institute of Diabetes and Digestive and Kidney Diseases (UC4 DK106955); National Institute of Diabetes and Digestive and Kidney Diseases (UC4 DK063865); National Center for Advancing Translational Sciences (UL1-TR001427); National Institute of Diabetes and Digestive and Kidney Diseases (P30‐DK‐017047); National Institute of Diabetes and Digestive and Kidney Diseases (UC4 DK063861); National Institute of Diabetes and Digestive and Kidney Diseases (UC4 DK063829); National Center for Advancing Translational Sciences (UL1 TR 000064); National Institute of Diabetes and Digestive and Kidney Diseases (U01DK063865); National Institute of Diabetes and Digestive and Kidney Diseases (U01DK63829); National Institute of Diabetes and Digestive and Kidney Diseases (UC4 DK095300); National Institute of Diabetes and Digestive and Kidney Diseases (U01DK63861); National Institute of Diabetes and Digestive and Kidney Diseases (UC4-DK-100238); National Institute of Diabetes and Digestive and Kidney Diseases (U01 DK63861, U01 DK63821); National Institute of Diabetes and Digestive and Kidney Diseases (U01 DK063790); National Institute of Diabetes and Digestive and Kidney Diseases (U01 DK063863); National Institute of Diabetes and Digestive and Kidney Diseases (U01 DK063861); National Institute of Diabetes and Digestive and Kidney Diseases (UC4 DK063821); National Institute of Diabetes and Digestive and Kidney Diseases (UC4 DK063863); National Institute of Diabetes and Digestive and Kidney Diseases (UC4 DK063836); National Institute of Diabetes and Digestive and Kidney Diseases (U01 DK063836); National Institute of Diabetes and Digestive and Kidney Diseases (U01 DK063821)
Según 9 financiadores declarados.
Publicación
- Publicado
- 2017-10-23 · Diabetes · vol. 67 · número 1 · págs. 146–154
- Editorial
- American Diabetes Association
- Citado
- 116 citas · más que el 98% de estudios similares · 7.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Diabetes and associated disorders · Digestive system and related health
- Palabras clave
- Vitamin D and neurology, Calcitriol receptor, Internal medicine, Endocrinology, Odds ratio, Medicine, Diabetes mellitus, Type 1 diabetes, Allele, Case-control study, vitamin D deficiency, Autoimmunity, Gastroenterology, Biology, Gene, Genetics, Disease
- MeSH
- humans, diabetes mellitus, type 1, genetic predisposition to disease, vitamin d, case-control studies, autoimmunity, polymorphism, single nucleotide, infant, infant, newborn, female, male
100 autores
- Jill M. Norris🇺🇸 · autor de correspondenciaColorado School of Public Health; University of Colorado Anschutz
- Jill M. Norris🇺🇸Colorado School of Public Health; University of South Florida; University of Colorado Anschutz
- Hye‐Seung Lee🇺🇸Colorado School of Public Health; University of South Florida; University of Colorado Anschutz
- Brittni Frederiksen🇺🇸🇫🇮Colorado School of Public Health; Finnish Institute for Health and Welfare; University of Colorado Anschutz
- Iris Erlund🇺🇸🇫🇮University of South Florida; Finnish Institute for Health and Welfare
- Ulla Uusitalo🇺🇸University of South Florida
- Jimin Yang🇸🇪🇺🇸Lund University; University of South Florida
- Åke Lernmark🇸🇪🇫🇮Lund University; Turku University Hospital
- Olli Simell🇫🇮University of Turku; Turku University Hospital
- Jorma Toppari🇫🇮🇺🇸University of Turku; Turku University Hospital; University of Colorado Anschutz
- Marian Rewers🇩🇪🇺🇸German Center for Diabetes Research; University of Colorado Anschutz
- Anette‐G. Ziegler🇺🇸🇩🇪Augusta University; German Center for Diabetes Research
- Jin-Xiong She🇺🇸Augusta University; University of Virginia
- Suna Onengut-Gumuscu🇺🇸University of Virginia
- Wei-Min Chen🇺🇸University of Virginia
- Stephen S. Rich🇫🇮🇺🇸Finnish Institute for Health and Welfare; University of Virginia
- Jouko Sundvall🇺🇸🇫🇮National Institutes of Health; Finnish Institute for Health and Welfare; National Institute of Diabetes and Digestive and Kidney Diseases
- Beena Akolkar🇺🇸National Institutes of Health; University of South Florida; National Institute of Diabetes and Digestive and Kidney Diseases
- Jeffrey Krischer🇺🇸🇫🇮University of South Florida; Finnish Institute for Health and Welfare; Pirkanmaa Hospital District; Tampere University Hospital; Tampere University
- Suvi M. Virtanen🇺🇸🇫🇮Pacific Northwest Diabetes Research Institute; Pirkanmaa Hospital District; Tampere University Hospital; Tampere University
- William Hagopian🇺🇸Pacific Northwest Diabetes Research Institute
- The TEDDY Study Group
- Marian Rewers🇺🇸University of Colorado Anschutz
- KIMBERLY BAUTISTA
- Judith Baxter
- Ruth Bedoy
- Daniel Felipe-Morales
- Kimberly Driscoll
- Brigitte I. Frohnert
- Patricia Gesualdo
- Michelle Hoffman
- Rachel Karban
- Edwin Liu
- Jill Norris🇺🇸Colorado School of Public Health; University of Colorado Anschutz
- Jill Norris🇺🇸 · autor de correspondenciaColorado School of Public Health; University of Colorado Anschutz
- Adela Samper-Imaz
- Andrea Steck
- Kathleen Waugh
- Hali Wright
- Jorma Toppari🇫🇮University of Turku; Turku University Hospital
- Olli G. Simell🇫🇮Turku University Hospital
- Annika Adamsson
- Suvi Ahonen
- Heikki Hyöty
- Jorma Ilonen
- Sanna Jokipuu
- Tiina Kallio
- Leena Karlsson
- Miia Kähönen
- Mikael Knip
- Lea Kovanen
- Mirva Koreasalo
- Kalle Kurppa
- Tiina Latva-aho
- Maria Lönnrot
- Elina Mäntymäki
- Katja Multasuo
- Juha Mykkänen
- Tiina Niininen
- Sari Niinistö
- Mia Nyblom
- Petra Rajala
- Jenna Rautanen
- Anne Riikonen
- Mika Riikonen
- Jenni Rouhiainen
- Minna Romo
- Tuula Simell
- Ville Simell
- Maija Sjöberg
- Aino Stenius
- Maria Leppänen
- Sini Vainionpää
- Eeva Varjonen
- Riitta Veijola
- Suvi M. Virtanen🇫🇮Pirkanmaa Hospital District; Tampere University Hospital; Tampere University
- Mari Vähä-Mäkilä
- Mari Åkerlund
- Katri Lindfors
- Jin-Xiong She🇺🇸Augusta University
- Desmond Schatz
- Diane Hopkins
- Leigh Steed
- Jamie Thomas
- Janey Adams
- Katherine Silvis
- Michael Haller
- Melissa Gardiner
- Richard McIndoe
- Ashok Sharma
- Joshua Williams
- Gabriela Young
- Stephen W. Anderson
- Laura Jacobsen
- Anette G. Ziegler🇩🇪German Center for Diabetes Research
- Andreas Beyerlein
- Ezio Bonifacio
- Michael Hummel
- Sandra Hummel
- Kristina Foterek
Resumen
El texto original del estudio, en el idioma en que se publicó.
We examined the association between plasma 25-hydroxyvitamin D [25(OH)D] concentration and islet autoimmunity (IA) and whether vitamin D gene polymorphisms modify the effect of 25(OH)D on IA risk. We followed 8,676 children at increased genetic risk of type 1 diabetes at six sites in the U.S. and Europe. We defined IA as positivity for at least one autoantibody (GADA, IAA, or IA-2A) on two or more visits. We conducted a risk set sampled nested case-control study of 376 IA case subjects and up to 3 control subjects per case subject. 25(OH)D concentration was measured on all samples prior to, and including, the first IA positive visit. Nine polymorphisms in VDR, CYP24A, CYP27B1, GC, and RXRA were analyzed as effect modifiers of 25(OH)D. Adjusting for HLA-DR-DQ and ancestry, higher childhood 25(OH)D was associated with lower IA risk (odds ratio = 0.93 for a 5 nmol/L difference; 95% CI 0.89, 0.97). Moreover, this association was modified by VDR rs7975232 (interaction P = 0.0072), where increased childhood 25(OH)D was associated with a decreasing IA risk based upon number of minor alleles: 0 (1.00; 0.93, 1.07), 1 (0.92; 0.89, 0.96), and 2 (0.86; 0.80, 0.92). Vitamin D and VDR may have a combined role in IA development in children at increased genetic risk for type 1 diabetes.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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