Cruciferous and Allium Vegetable Intakes are Inversely Associated With 15-Year Atherosclerotic Vascular Disease Deaths in Older Adult Women
Blekkenhorst LC, Bondonno CP, Lewis JR, Devine A, Zhu K, Lim WH, Woodman RJ, Beilin LJ, Prince RL, Hodgson JM
Journal of the American Heart Association · 44 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Healthway
- Gobierno
- Medical Research Council
- Gobierno
- National Health and Medical Research Council
- Subvenciones
- National Health and Medical Research Council (572604); National Health and Medical Research Council (1084922); National Health and Medical Research Council (254627, 303169 and 572604); National Health and Medical Research Council (303169); Healthway (572604); Healthway (254627); Healthway (303169); National Health and Medical Research Council (254627)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-10-11 · J Am Heart Assoc · vol. 6 · número 10
- Editorial
- Wiley
- Citado
- 57 citas · más que el 97% de estudios similares · 7.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Nutritional Studies and Diet · Garlic and Onion Studies · Antioxidant Activity and Oxidative Stress
- Palabras clave
- Cruciferous vegetables, Medicine, Disease, Gerontology, Internal medicine, Cancer
- MeSH
- humans, brassicaceae, allium, vegetables, prognosis, multivariate analysis, proportional hazards models, risk factors, chi-square distribution, longitudinal studies, prospective studies, risk reduction behavior, age factors, sex factors, nutritional status, nutritive value, time factors, aged, western australia, female, atherosclerosis, phytochemicals, recommended dietary allowances, protective factors, diet, healthy
10 autores
- Lauren C. Blekkenhorst🇦🇺The University of Western Australia; Royal Perth Hospital
- Catherine P. Bondonno🇦🇺Edith Cowan University; The University of Western Australia; Royal Perth Hospital
- Joshua Richard Lewis🇦🇺The University of Sydney; The University of Western Australia; Children's Hospital at Westmead; Queen Elizabeth II Medical Centre
- Amanda Devine🇦🇺Edith Cowan University
- Kun Zhu🇦🇺The University of Western Australia; Sir Charles Gairdner Hospital; Queen Elizabeth II Medical Centre
- Wai H. Lim🇦🇺The University of Western Australia; Sir Charles Gairdner Hospital; Queen Elizabeth II Medical Centre
- Richard John Woodman🇦🇺Flinders University
- Lawrence Joseph Beilin🇦🇺The University of Western Australia; Royal Perth Hospital
- Richard Lewis Prince🇦🇺The University of Western Australia; Sir Charles Gairdner Hospital; Queen Elizabeth II Medical Centre
- Jonathan M. Hodgson🇦🇺Edith Cowan University; The University of Western Australia; Royal Perth Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Higher vegetable intake is consistently associated with lower atherosclerotic vascular disease (ASVD) events. However, the components responsible and mechanisms involved are uncertain. Nonnutritive phytochemicals may be involved. The objective of this study was to investigate the associations of total vegetable intake and types of vegetables grouped according to phytochemical constituents with ASVD mortality.
Methods and results
The cohort consisted of 1226 Australian women aged 70 years and older without clinical ASVD or diabetes mellitus at baseline (1998). Vegetable intakes were calculated per serving (75 g/d) and were also classified into prespecified types relating to phytochemical constituents. ASVD-related deaths were ascertained from linked mortality data. During 15 years (15 947 person-years) of follow-up, 238 ASVD-related deaths occurred. A 1-serving increment of vegetable intake was associated with a 20% lower hazard of ASVD-related death (multivariable-adjusted hazard ratio, 0.80; 95% confidence interval, 0.69-0.94 [P=0.005]). In multivariable-adjusted models for vegetable types, cruciferous (per 10-g/d increase: hazard ratio, 0.87; 95% confidence interval, 0.81-0.94 [PP=0.003]) vegetables were inversely associated with ASVD-related deaths. The inclusion of other vegetable types, as well as lifestyle and cardiovascular risk factors, did not alter these associations. Yellow/orange/red (P=0.463), leafy green (P=0.063), and legume (P=0.379) vegetables were not significant.
Conclusions
Consistent with current evidence, higher cruciferous and allium vegetable intakes were associated with a lower risk of ASVD mortality. In addition, cruciferous and allium vegetables are recognized to be a good source of several nonnutritive phytochemicals such as organosulfur compounds.
Clinical trial registration
URL: http://www.anzctr.org.au. Unique identifier: ACTRN12617000640303.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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