Physiological serum 25-hydroxyvitamin D concentrations are associated with improved thyroid function-observations from a community-based program
Mirhosseini N, Brunel L, Muscogiuri G, Kimball S
Endocrine · 42 citas
Cómo se estudió
- Diseño
- Estudio de casos y controles (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-10-24 · Endocrine · vol. 58 · número 3 · págs. 563–573
- Editorial
- Springer Science+Business Media
- Citado
- 60 citas · más que el 92% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Thyroid Disorders and Treatments · Thyroid Cancer Diagnosis and Treatment
- Palabras clave
- Euthyroid, Subclinical infection, Medicine, Vitamin D and neurology, Thyroid function, Internal medicine, Endocrinology, Thyroid, vitamin D deficiency, Thyroid disease, Diabetes mellitus, Thyroid function tests
- MeSH
- thyroid gland, humans, vitamin d deficiency, hypothyroidism, vitamins, vitamin d, immunoglobulins, thyroid-stimulating, thyroid function tests, case-control studies, follow-up studies, nutritional status, dietary supplements, databases, factual, adolescent, adult, aged, aged, 80 and over, middle aged, health promotion, community health services, female, male
4 autores
- Naghmeh Zahra Mirhosseini🇨🇦Pure North
- Ludovic Brunel
- Giovanna Muscogiuri
- Samantha Kimball🇨🇦 · autor de correspondenciaSt. Mary's University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Vitamin D deficiency has been associated with an increased risk of hypothyroidism and autoimmune thyroid disease. Our aim was to investigate the influence of vitamin D supplementation on thyroid function and anti-thyroid antibody levels.
Methods
We constructed a database that included 11,017 participants in a health and wellness program that provided vitamin D supplementation to target physiological serum 25-hydroxyvitmain D [25(OH)D] concentrations (>100 nmol/L). Participant measures were compared between entry to the program (baseline) and follow-up (12 ± 3 months later) using an intent-to-treat analysis. Further, a nested case-control design was utilized to examine differences in thyroid function over 1 year in hypothyroid individuals and euthyroid controls.
Results
More than 72% of participants achieved serum 25(OH)D concentrations >100 nmol/L at follow-up, with 20% above 125 nmol/L. Hypothyroidism was detected in 2% (23% including subclinical hypothyroidism) of participants at baseline and 0.4% (or 6% with subclinical) at follow-up. Serum 25(OH)D concentrations ≥125 nmol/L were associated with a 30% reduced risk of hypothyroidism and a 32% reduced risk of elevated anti-thyroid antibodies. Hypothyroid cases were found to have higher mean serum 25(OH)D concentrations at follow-up, which was a significant positive predictor of improved thyroid function.
Conclusion
The results of the current study suggest that optimal thyroid function might require serum 25(OH)D concentrations above 125 nmol/L. Vitamin D supplementation may offer a safe and economical approach to improve thyroid function and may provide protection from developing thyroid disease.
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