Financiado en parte por Lloyd's Tercentenary Research Foundation, H. Lundbeck A/S, Lundbeck Foundation, The Lundbeck Foundation
Prenatal vitamin D supplementation reduces risk of asthma/recurrent wheeze in early childhood: A combined analysis of two randomized controlled trials
Wolsk HM, Chawes BL, Litonjua AA, Hollis BW, Waage J, Stokholm J, Bønnelykke K, Bisgaard H, Weiss ST
PloS one · 150 citas
Etiquetas de revisión
Vínculos de autores con la industriaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- Strategiske Forskningsråd
- Organización sin fines de lucro
- European Respiratory Society
- Empresa
- Lloyd's Tercentenary Research Foundation
- Organización sin fines de lucro
- Lundbeckfonden
- Gobierno
- Ministeriet Sundhed Forebyggelse
- Empresa
- H. Lundbeck A/S
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NHLBI NIH HHS
- Empresa
- Lundbeck Foundation
- Gobierno
- National centers for Advancing Translational Sciences
- Gobierno
- NCATS NIH HHS
- Gobierno
- The Danish Ministry of Health
- Empresa
- The Lundbeck Foundation
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- National Heart, Lung, and Blood Institute (R01HL091528); Strategiske Forskningsråd (0603–00280B); Lundbeckfonden (R16‐A1694); Ministeriet Sundhed Forebyggelse (903516); European Respiratory Society (Fellowship, LTRF, 2016); National Center for Advancing Translational Sciences (U54TR001012); Lundbeckfonden (R210-2015-3410); Lundbeckfonden (R191-2015.1571); National Heart, Lung, and Blood Institute (U01HL091528); National Institutes of Health (U54 TR001012); National Institutes of Health (HL091528)
Según 15 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-10-27 · PLoS One · vol. 12 · número 10 · pág. e0186657
- Editorial
- Public Library of Science
- Citado
- 223 citas · más que el 100% de estudios similares · 21.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Asthma and respiratory diseases · Birth, Development, and Health
- Palabras clave
- prenatal vitamin D supplementation, vitamin D3, asthma, recurrent wheezing, childhood asthma, individual patient data meta-analysis, atopic dermatitis, lower respiratory tract infection, specific IgE, total IgE
- MeSH
- humans, asthma, recurrence, respiratory sounds, vitamin d, placebos, prenatal care, pregnancy, child, preschool, female, randomized controlled trials as topic
9 autores
- Helene Mygind Wolsk🇩🇰🇺🇸University of Copenhagen; Brigham and Women's Hospital; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
- Bo Chawes🇩🇰🇺🇸University of Copenhagen; Brigham and Women's Hospital; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
- Augusto A. Litonjua🇺🇸Brigham and Women's Hospital; Harvard University
- Bruce W. Hollis🇺🇸Medical University of South Carolina
- Johannes Waage🇩🇰University of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
- Jakob Stokholm🇩🇰University of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
- Klaus Bønnelykke🇩🇰University of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
- Hans Flinker Bisgaard🇩🇰University of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
- Scott T. Weiss🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
We recently published two independent randomized controlled trials of vitamin D supplementation during pregnancy, both indicating a >20% reduced risk of asthma/recurrent wheeze in the offspring by 3 years of age. However, neither reached statistical significance.
Objective
To perform a combined analysis of the two trials and investigate whether maternal 25-hydroxy-vitamin D (25(OH)D) level at trial entry modified the intervention effect.
Methods
VDAART (N = 806) and COPSAC2010. (N = 581) randomized pregnant women to daily high-dose vitamin D3 (4,000 IU/d and 2,400 IU/d, respectively) or placebo. All women also received a prenatal vitamin containing 400 IU/d vitamin D3. The primary outcome was asthma/recurrent wheeze from 0-3yrs. Secondary end-points were specific IgE, total IgE, eczema and lower respiratory tract infections (LRTI). We conducted random effects combined analyses of the treatment effect, individual patient data (IPD) meta-analyses, and analyses stratified by 25(OH)D level at study entry.
Results
The analysis showed a 25% reduced risk of asthma/recurrent wheeze at 0-3yrs: adjusted odds ratio (aOR) = 0.74 (95% CI, 0.57-0.96), p = 0.02. The effect was strongest among women with 25(OH)D level ≥30ng/ml at study entry: aOR = 0.54 (0.33-0.88), p = 0.01, whereas no significant effect was observed among women with 25(OH)D level <30ng/ml at study entry: aOR = 0.84 (0.62-1.15), p = 0.25. The IPD meta-analyses showed similar results. There was no effect on the secondary end-points.
Conclusions
This combined analysis shows that vitamin D supplementation during pregnancy results in a significant reduced risk of asthma/recurrent wheeze in the offspring, especially among women with 25(OH)D level ≥ 30 ng/ml at randomization, where the risk was almost halved. Future studies should examine the possibility of raising 25(OH)D levels to at least 30 ng/ml early in pregnancy or using higher doses than used in our studies.
Trial registration
COPSAC2010: ClinicalTrials.gov NCT00856947; VDAART: ClinicalTrials.gov NCT00920621.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.