Cutaneous reactive hyperaemia is unaltered by dietary nitrate supplementation in healthy humans
Wong BJ, Keen JT, Levitt EL
Clinical physiology and functional imaging · 6 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Kansas
Según 1 financiador declarado.
Publicación
- Publicado
- 2017-10-29 · Clin Physiol Funct Imaging · vol. 38 · número 5 · págs. 772–778
- Editorial
- Wiley
- Citado
- 8 citas · más que el 68% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 53 trabajos
- Acceso
- De pago
- Áreas de investigación
- Thermoregulation and physiological responses · Nitric Oxide and Endothelin Effects · Heart Rate Variability and Autonomic Control
- Palabras clave
- Hyperaemia, Medicine, Blood pressure, Reactive hyperemia, Vasodilation, Laser Doppler velocimetry, Nitrate, Microdialysis, Internal medicine, C-reactive protein, Blood flow, Anesthesia, Cardiology, Endocrinology, Chemistry, Inflammation
- MeSH
- microcirculation, skin, humans, beta vulgaris, plant roots, hyperemia, nitrates, blood flow velocity, laser-doppler flowmetry, blood pressure, regional blood flow, vasodilation, time factors, dietary supplements, adult, female, male, young adult, healthy volunteers, fruit and vegetable juices
3 autores
- Brett James Wong🇺🇸 · autor de correspondenciaGeorgia State University; Kansas State University
- Jeremy Thomas Keen🇺🇸Kansas State University
- Erica Lynne Levitt🇺🇸Kansas State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
The purpose of this study was to determine whether nitrate supplementation augments cutaneous reactive hyperaemia. Seven participants were tested pre- and postnitrate supplementation (25 ml beetroot juice); participants consumed one shot per day for 3 days. Participants were instrumented with two microdialysis fibres: control (Ringer's solution) and NO synthase inhibition (20 mM L-NAME). Skin blood flow was measured via laser-Doppler flowmetry (LDF). A blood pressure cuff was placed on the experimental arm and inflated to 250 mmHg for 5 mins to occlude arterial inflow. The cuff was released, and the resultant reactive hyperaemia was measured. Blood pressure was continuously measured via plethysmography from a finger on the non-experimental arm. Cutaneous vascular conductance was calculated (LDF/MAP) and normalized to maximal vasodilatation (%CVCmax ). Only diastolic blood pressure was reduced following nitrate supplementation (71 ± 2 vs. 66 ± 1 mmHg; Pmax ) or L-NAME (Pre: 52 ± 2 vs. Post: 59 ± 4%CVCmax ) sites. There was no effect of nitrate supplementation on total reactive hyperaemia at either control (Pre: 4197 ± 943 vs. Post: 4523 ± 1040%CVCmax * sec) or L-NAME (Pre: 5108 ± 997 vs. Post: 5694 ± 1002%CVCmax * sec) sites. These data suggest cutaneous reactive hyperaemia is unaffected by dietary nitrate supplementation in healthy humans.
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