Association of whole grain intake with all-cause, cardiovascular, and cancer mortality: a systematic review and dose-response meta-analysis from prospective cohort studies
Zhang B, Zhao Q, Guo W, Bao W, Wang X
European journal of clinical nutrition · 78 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2017-11-01 · Eur J Clin Nutr · vol. 72 · número 1 · págs. 57–65
- Editorial
- Springer Nature
- Citado
- 122 citas · más que el 89% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 55 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nutritional Studies and Diet · Food composition and properties · Natural Products and Applications
- Palabras clave
- whole grain intake, all-cause mortality, cardiovascular mortality, cancer mortality, dose-response relationship, dietary guidelines, diet and mortality, prospective cohort, nonlinear relationship, dietary fiber, nutrition education, nutrition research funding
- MeSH
- humans, neoplasms, cardiovascular diseases, mortality, risk, evidence-based medicine, whole grains, diet, healthy
5 autores
- B Zhang🇨🇳Shandong University
- Qiu Zhao🇨🇳Shandong University; Qilu Hospital of Shandong University
- Wei Guo🇨🇳Shandong University
- W Bao🇺🇸University of Iowa
- Xianliang Wang🇨🇳 · autor de correspondenciaShandong University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/objectives
Whole grains are rich source of nutrients and have shown beneficial effects on human health. This study was designed to systematically review the existing results and quantitatively assess the dose-response relationship of whole grain intake with all-cause and cause-specific mortality.
Subjects/methods
We searched 'whole grain' or 'whole grains' in combination with 'mortality'' or 'cardiovascular disease' or 'cancer' through the Web of Science and PubMed databases till 20 January 2016. To be eligible for inclusion, publications should be prospective cohort studies and reported the influence of whole grain intake on human mortality. Relative risks (RRs) and 95% confidence intervals (CIs) from the included studies were pooled by a random effects model or fixed effect model.
Results
We included 19 cohort studies from 17 articles, with 1 041 692 participants and 96 710 deaths in total, in the analyses. We observed an inverse relationship of whole grain intake with risk of total, cardiovascular disease and cancer mortality. The pooled RR was 0.84 (95% CI 0.81-0.88, n=9) for total mortality, 0.83 (95% CI 0.79-0.86, n=8) for CVD mortality and 0.94 (95% CI 0.87-1.01, n=14) for cancer mortality, comparing the highest intake of whole grain with the lowest category. For dose-response analysis, we found a nonlinear relationship of whole grain intake with risk of total, cardiovascular and cancer mortality. Each 28 g/d intake of whole grains was associated with a 9% (pooled RR: 0.91 (0.90-0.93)) lower risk for total mortality, 14% (pooled RR: 0.86 (0.83-0.89)) lower risk for CVD mortality and 3% (pooled RR: 0.97 (0.95-0.99)) lower risk for cancer mortality.
Conclusions
Our study shows that whole grain intake was inversely associated with risk of total, CVD and cancer mortality. Our results support current dietary guidelines to increase the intake of whole grains. Government officials, scientists and medical staff should take actions to promote whole grains intake.
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